by
The Los Angeles Dodgers and Arizona Diamondbacks are set to kick off a four-game series on Thursday night at Chase Field in Phoenix. The Dodgers are the betting favorites to win the world series and one of the most in-form teams in the MLB, meaning the Diamondbacks will start the match and mini-series as the underdogs. Find out who will win the opening match in our latest MLB betting picks.
- What: MLB
- Who: Arizona Diamondbacks vs. LA Dodgers
- Where: Chase Field, Phoenix, Arizona
- When: Thursday, May 8th, 2025
- Time: 9.40 p.m. ET
The two teams prepared for the series opener with very contrasting results.
The Diamondbacks suffered a heavy 7-1 defeat at home against the Mets, dropping their record at Chase Field to a disappointing 9-10.
In contrast, the Dodgers cruised to a dominant 10-1 victory over the Miami Marlins at LoanDepot Park, improving their road record to 10-9.
Los Angeles is currently +125 to win the series, with Arizona at +300 and a tie priced at +170. Now, let’s take a look at the odds for tonight’s opening game at Chase Field.
Arizona Diamondbacks vs. LA Dodgers Betting
The top MLB betting sites are backing the LA Dodgers for the win.
Los Angeles is priced at -160 on the money line, while the Diamondbacks are listed at +135.
On the spread, Arizona is getting a +1.5 run head start. With that advantage, the Diamondbacks are -125 to cover, while the Dodgers are +105 to win by two or more.
The total runs line is set at 8.5, with both the Over and Under priced evenly at -110.
Find more wagering options on our betting table below. All our odds for the match between the Arizona Diamondbacks and the LA Dodgers are taken from the best MLB baseball betting sites in 2025.
For more information on baseball betting, you can check out our World Series Betting Guide page.
| Diamondbacks vs Dodgers |  |  |  |
| Diamondbacks | +135 | +135 | +135 |
| Dodgers | -160 | -160 | -160 |
| Diamondbacks (+1.5) | -125 | -125 | -125 |
| Dodgers (-1.5) | +105 | +105 | +105 |
| Over 8.5 | -110 | -110 | -110 |
| Under 8.5 | -110 | -110 | -110 |
LA Dodgers
The Los Angeles Dodgers started the season impressively with a 6-0 winning streak.
Although they have dropped off that pace in recent times, the Dodgers have continued to impress with their combination of elite pitching and explosive offense.
Led by a deep rotation and a stacked lineup featuring the likes of Mookie Betts, Freddie Freeman, and Shohei Ohtani, the Dodgers have consistently performed both at home and on the road.
Their bats have come alive in recent weeks, and they’ve strung together a series of convincing wins, including a 10-1 rout of the Miami Marlins in their most recent outing.
FINAL: #Dodgers 10, Marlins 1 pic.twitter.com/Bb3i0UsK1T
— Los Angeles Dodgers (@Dodgers) May 7, 2025
And while their bullpen has occasionally been vulnerable, their starting pitching and run production have largely compensated.
The Dodgers are the favorites to win everything this season. Dave Roberts’ team is just -700 to win the NL West Division. The Dodgers are also +140 to win the National League title, and they are the clear +230 betting favorites to retain the World Series.
Arizona Diamondbacks
Arizona has had a mixed start to the 2025 campaign, struggling to find consistency in a competitive NL West.
After last season’s playoff push, expectations were high, but the team has yet to hit its stride.
Offensively, they’ve shown flashes of potential, but have too often been let down by uneven pitching performances and a leaky bullpen.
Their 7-1 home loss to the New York Mets on Wednesday highlighted their ongoing struggles at Chase Field, where they’ve posted a sub-.500 record.
Despite these challenges, the D-backs remain a dangerous team with enough talent to turn things around. Especially if their key hitters can find rhythm and their rotation stabilizes.
Arizona is +1500 to win the NL West. They are also now odds against reaching the playoffs at +110.
Torey Lovullo’s team is +1600 to win the National League and +3300 to win the 2025 World Series.
Arizona Diamondbacks vs. LA Dodgers Betting Picks and Prediction
The Dodgers enter the matchup with a strong 25-12 record, while the Diamondbacks stand at 19–18. In their ten matches, LA is 8-2 and the Diamondbacks are 5-5.
Both teams were involved in high-scoring affairs on Wednesday. This makes a bet on over 8.5 runs in the total runs market the way to go.
For our match winner prediction, we are expecting the Dodgers to carry momentum into the game and record the win.
Los Angeles enters with the edge in both form and firepower.
Yoshinobu Yamamoto has been outstanding on the road, boasting a sub-1.00 ERA, and he will face a Diamondbacks lineup that has struggled to score consistently in recent games.
Arizona’s Brandon Pfaadt has been solid at home this season, but he has lacked support, and it should be impossible for him to keep the Dodgers quiet on his own.
We can see a similar outcome to last night for the Dodgers, where things are tight early on, but LA’s depth will break through in the middle innings and secure the win.
With LA’s odds short on the money line, we are backing them to win on the run line for our betting pick.
Please check out our recommended partner sites below. These are the Best Offshore Sportsbooks for US Bettors 2025 and MLB betting:
Sports Betting Sites 