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- What? MLB: Toronto Blue Jays vs. Boston Red Sox
- Where? Rogers Centre, Toronto
- When? Tuesday, September 23, 2025 at 7:07 p.m. ET
The American League East spotlight shifts to Toronto on Tuesday night, where the division-leading Blue Jays (90-66) welcome the Boston Red Sox (85-71), who currently sit in third place. First pitch is scheduled for 7:07 p.m. ET at Rogers Centre and the MLB betting lines see Toronto as the -155 favorite with Boston at +140.
On the mound, Kevin Gausman will get the call for the Blue Jays, entering with a 10-10 record. Boston will counter with Lucas Giolito, who brings a 10-4 mark into this crucial late-season showdown.
Below are the odds from three of the best MLB Baseball betting sites.
| MLB |  |  |  |
| Boston Red Sox | +133 | +140 | +140 |
| Toronto Blue Jays | -159 | -155 | -155 |
| Boston Red Sox +1.5 | -160 | -150 | -150 |
| Toronto Blue Jays -1.5 | +135 | +130 | +130 |
| Over 8.0 | -105 | -107 | -107 |
| Under 8.0 | -115 | -113 | -113 |
Toronto Blue Jays
Toronto is coming off an 8-5 victory over the Kansas City Royals on Sunday, powered by Vladimir Guerrero Jr., who went 2-for-5 with a double and a pair of RBIs. Seranthony Dominguez earned the win after 1 1/3 spotless innings, striking out two without allowing a hit or run.
The Blue Jays have thrived in the favorite’s role this year, posting a 47-34 record when backed on the moneyline, good for a 58% success rate. Totals have also leaned toward the over in their games, with 83 of 155 matchups surpassing the line (83-64-8).
At the plate, Toronto’s offense has been among the league’s most productive. Their 768 runs rank fifth overall, averaging 4.9 per outing. The team has clubbed 182 home runs—12th most in MLB—while hitting .267 collectively, the top batting average in the majors. They also strike out just 6.8 times per game, the second-lowest rate of any team.
On the pitching side, the Blue Jays’ staff averages 8.9 strikeouts per nine innings, ranking fifth in baseball, though their 4.23 ERA sits 19th. Kevin Gausman will make his 31st start of the campaign, carrying a 10-10 record with a 3.38 ERA and 177 strikeouts across 183 2/3 innings.
Individually, Guerrero Jr. has been a cornerstone with 169 hits, a .389 on-base percentage, and a .481 slugging mark. George Springer has brought the power, pacing the club with 30 homers to go along with 80 RBIs and a .552 slugging percentage. Ernie Clement has chipped in with a .279/.315/.401 slash line, while Alejandro Kirk has contributed steady production at .285 with a .352 OBP and .407 slugging.
Boston Red Sox
Boston dropped its series finale against Tampa Bay on Sunday, falling 7-3. Romy Gonzalez provided a spark at the plate by going 2-for-2 with an RBI, while starter Connelly Early was tagged with the loss after allowing two earned runs on three hits over four innings, striking out four in the process.
The Red Sox have been competitive when cast as underdogs this year, winning 27 of 55 such games for a 49.1% clip. Totals have leaned to the high side in Boston’s contests, with 74 of their 155 outings finishing over the number.
Offensively, the Red Sox sit just behind Toronto in overall production, ranking sixth in the majors with 765 runs. Their 182 home runs place them 12th, and their .255 team batting average is fourth-best in MLB. They do, however, strike out more frequently than most lineups, averaging 8.7 per game, which ranks 23rd.
On the pitching side, Boston’s staff has been a strength. They average 8.5 strikeouts per nine innings (15th in MLB) and collectively own a 3.77 ERA, the fifth-lowest in baseball. Lucas Giolito will take the mound for his 26th start of the season, entering with a 10-4 record.
Individually, Jarren Duran has been a versatile threat with 39 doubles, 13 triples, 16 homers, and 59 walks while hitting .260. Trevor Story leads the way in power production, topping the team with 25 homers and 95 RBIs, while also carrying a .264 batting average. Alex Bregman has contributed steady offense with a .278 mark, 27 doubles, 18 long balls, and 49 walks. Meanwhile, Ceddanne Rafaela has added 31 doubles, three triples, and 16 homers while batting .244.
Toronto Blue Jays vs. Boston Red Sox Prediction and Betting Picks
With the regular season winding down, both sides enter this series hungry for results—Toronto looking to lock up the division crown, while Boston battles to maintain its grip on a Wild Card spot. The Blue Jays have thrived at Rogers Centre, taking four of their last five meetings with Boston there and emerging as the league’s most profitable home team for bettors this year. Although the Red Sox have proven capable away from Fenway, Toronto’s recent dominance at home gives them the upper hand.
Based on the matchup, the Over looks like the better side. Both clubs rank inside the top six in runs scored and carry batting averages well above league average. Toronto leads all of MLB in team batting average, while Boston sits fourth, which means consistent contact and plenty of chances with runners on base.
Even though Gausman and Giolito are quality starters, both lineups are strong enough to pressure them early, and the bullpens haven’t been lockdown units. With Toronto games topping the number 83 times this season and Boston hitting overs in 74 contests, the trends lean toward another high-scoring outcome.
See below, our partner table of the best offshore sportsbooks where you can place your Toronto Blue Jays vs. Boston Red Sox bets.
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