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The New York Yankees and Los Angeles Angels are set to begin a three-game series at Angel Stadium in Anaheim on Monday. The opener is scheduled for 9:38 p.m. ET, with subsequent games on Tuesday and Wednesday. Below we name our MLB betting picks for the opening match of the series.
- What: MLB
- Who: LA Angels vs. New York Yankees
- Where: Angel Stadium, Anaheim, CA
- When: Monday, May 26th, 2025
- Time: 9.38 p.m. ET
The Yankees enter the series with a 31-20 record, leading the AL East. They are coming off a dominant series win over the Colorado Rockies, highlighted by a 13-1 win in the second match of the three-game series.
The Angels have suffered a setback over the weekend. Back-to-back defeats to the Marlins not only saw their eight-match winning streak come to an end but also resulted in Ron Washington’s team losing the series 2-1.
LA Angels vs. New York Yankees Betting
After clinching their series against the Rockies over the weekend, the best MLB betting sites also favor the Yankees to get their series against the Angels off to a winning start.
The Yankees are -165 to win the opening match on the money line, with the Angels at +140.
On the run line, it’s the Angels receiving the +1.5-run advantage. LA is -120 with the spread in their favour. The Yankees are +100 to win by two points or more and cover.
The total run line is set at 9.5. Under is the favorite at -120, with over at +100.
Find more wagering options on our betting table below. All our odds for the match between the LA Angels and the New York Yankees are taken from the best MLB baseball betting sites in 2025.
For more information on baseball betting, you can check out our World Series Betting Guide page.
LA Angels
The Los Angeles Angels have experienced a season of highs and lows in 2025, they currently hold a 25–27 record, placing them fourth in the American League West.
Despite their lowly position in the standings, the Angels have shown strong form in recent weeks – most notably during an impressive eight-game winning streak that included sweeps of both the Dodgers and Athletics.
The surge of positive results was fueled by standout performances from the likes of Taylor Ward, who hit his 15th home run during this stretch, and catcher Logan O’Hoppe, whose offensive contributions have been pivotal.
However, the Angels’ momentum was halted in their three-game series against the Miami Marlins. This started with a 6-2 loss on Saturday. The setback was compounded by a 3-0 shutout defeat to the same opponents on Sunday.
The losses snapped LA’s winning streak and highlighted ongoing challenges, particularly in pitching depth and consistency.
As they prepare to face the New York Yankees, the Angels aim to address these issues and capitalize on their offensive strengths to improve their standing in the division – which isn’t too bad overall, as they are only four games behind the Mariners who sit top.
LA is +35000 to win the World Series and +3500 to top the AL West in the regular season.
New York Yankees
The New York Yankees ead the American League East by 6 games over the Tampa Bay Rays. New York’s +106 run differential is the best in the AL, reflecting a potent offense that has scored 291 runs while allowing just 185.
Offensively, Aaron Judge has been a standout, boasting a .423 batting average, .510 on-base percentage, and .777 slugging percentage, with 11 home runs and 33 RBIs. Jasson Domínguez has also contributed significantly, including a walk-off homer against the Texas Rangers on May 22.
On the mound, the Yankees’ pitching staff has been formidable. Rookie Will Warren has shown promise, recently striking out 10 batters in 5.2 innings against the Rangers.
The Yankees’ consistent performance positions them as strong contenders as the season progresses. They are +750 second-favorites to win the 2025 World Series.
LA Angels vs. New York Yankees Betting Picks and Prediction
Tonight’s matchup between the New York Yankees and the Los Angeles Angels opens a three-game set in Anaheim. The Yankees enter as solid favorites.
Ryan Yarbrough takes the mound for New York against Angels right-hander Jack Kochanowicz, who has struggled with consistency this season.
Given the Yankees’ dominant run differential and recent offensive surge, backing them for the win looks like the safest play.
For more value, consider the Yankees on the run line at -1.5, especially with the Angels’ pitching vulnerabilities and the firepower New York boasts in its lineup – particularly from Aaron Judge, who has been in excellent form in recent days and weeks.
Although the Yankees have only covered the spread in one of their last five matches, we still feel backing them to win by over 1.5 points makes more sense. They are on a run of 8-2 in their previous ten matches, after all.
The over 9.5 total runs are also an appealing option. Both lineups are capable of scoring in bunches and Kochanowicz has had issues with run prevention.
As well as backing New York to win on the run line, we are also recommending over 9.5 runs at +100.
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