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The New York Yankees and the New York Mets will kick off a three-game series in the Bronx on Friday. The Yankees are the betting favorites to win and also one of the favorites to win the world series. Find out who will win the opening match in our latest MLB betting picks.
- What: MLB
- Who: New York Yankees vs. New York Mets
- Where: Yankee Stadium, Bronx, New York
- When: Friday, May 16th, 2025
- Time: 7.05 p.m. ET
The Subway Series reignites this Friday, as the New York Yankees host the New York Mets at Yankee Stadium, with first pitch scheduled for 7:05 PM.
This matchup marks the first of six interleague games between the crosstown rivals in the 2025 season, part of MLB’s designated “Rivalry Weekend.”
The rivalry has intensified following the Mets’ acquisition of former Yankee star Juan Soto on a record-breaking 15-year, $765 million contract . Soto’s return to the Bronx in a Mets uniform adds a compelling narrative to an already heated competition.
New York Yankees vs. New York Mets Betting
The top MLB betting sites are backing the New York Yankees to win the opening match of the series.
The Yankees are -150 to win on the money line and +145 to win on the run line and cover the 1.5-run spread.
As for the Mets, they are +125 to win on the money line and -170 to win with the +1.5-run advantage on the handicap spread line.
The total runs is set at 8.5. Over is the favorite at -120, and under is +100.
To win the series, the New York Yankees are favored at -165, and the Mets are +135.
Find more wagering options on our betting table below. All our odds for the match between the New York Yankees and the New York Mets are taken from the best MLB baseball betting sites in 2025.
For more information on baseball betting, you can check out our World Series Betting Guide page.
| Yankees vs. Mets |  |  |  |
| Yankees | -150 | -150 | -150 |
| Mets | +125 | +125 | +125 |
| Yankees (-1.5) | +145 | +145 | +145 |
| Mets (+1.5) | -170 | -170 | -170 |
| Over 8.5 | -120 | -120 | -120 |
| Under 8.5 | +100 | +100 | +100 |
New York Yankees
The New York Yankees are entering their Subway Series against the New York Mets in strong form. They concluded their West Coast trip with a 3-2 victory over the Seattle Mariners, which secured the series and capped a successful road stretch.
In their latest game, Aaron Judge delivered a decisive 444-foot home run in the eighth innings, marking his MLB-leading 15th homer of the season and the hardest-hit ball at T-Mobile Park in the Statcast era.
Paul Goldschmidt contributed with a pinch-hit homer, his first in 14 years, while rookie pitcher Will Warren impressed with a career-high nine strikeouts over five innings.
The Yankees’ bullpen, featuring Tyler Matzek, Ian Hamilton, and Fernando Cruz, effectively kept the Mariners at bay. Luke Weaver secured the save by striking out the side in the ninth inning.
Aaron Boone’s team is now just -240 to win the regular-season AL East Division. They are also the +270 favorites to win the American League and the +750 second favorites to win the World Series.
The LA Dodgers are the favorites at +225.
New York Mets
The New York Mets enter the upcoming Subway Series against the Yankees with a 28–16 record. Leading the NL East, they’ve gone 7-6 in May, showing some inconsistency.
Recently, the Mets won two out of three games against the Pittsburgh Pirates, including a 2–1 victory on May 13. However, they were shut out 4–0 in the series finale on May 14, ending a three-game winning streak.
In that loss, starting pitcher Clay Holmes allowed four runs over six innings, including two home runs. The Mets’ offense managed six hits but failed to capitalize.
The Mets are -140 to win the NL East Division, +450 to win the National League, and the +900 third favorites to win the 2025 World Series.
New York Yankees vs. New York Mets Betting Picks and Prediction
Both teams have demonstrated strong offensive capabilities this season. The Yankees are averaging 5.81 runs per game. Over their last 20 matches, they have been even more productive, averaging 6.05 runs per game.
The Mets are some distance behind on 4.65 runs per game. Even taking the Mets’ poorer scoring rates, betting on the game total to go over 8.5 runs appears to be a solid choice.
The Yankees hold a 13-8 record at home, though it’s fair to say that mark could be stronger. The Mets are an even 11-11 on the road.
Both teams come into this clash with a 6-4 record over their last ten games. But as the saying goes, when it comes to local rivalries, the form book often goes out the window.
Still, a pick has to be made. The Yankees are priced at -150 on the money line and +145 on the run line, both offering potential value.
Given that both teams have been involved in games with both narrow and wide margins recently, and with a lean toward the over 8.5 total runs, backing the Yankees on the run line at the better odds makes more sense.
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