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The Portland Trail Blazers will open their 2025-26 NBA campaign on Wednesday, October 22, when they host the Minnesota Timberwolves at the Moda Center. Tipoff is scheduled for 10 p.m. ET, with television coverage available on KUNP and FDSN.
NBA Basketball betting sites have installed Minnesota as a 4.5-point favorite for the season opener, while the total for the contest sits at 221.5 points.
- What? NBA: Minnesota Timberwolves vs. Portland Trail Blazers
- Where? Moda Center, Portland
- When? Wednesday, October 22, 2025 10 p.m. ET
Below are the NBA betting lines from three of the best offshore sportsbooks.
| NBA |  |  |  |
| Minnesota Timberwolves | -175 | -175 | -185 |
| Portland Trail Blazers | +153 | +153 | +148 |
| Minnesota Timberwolves -4.5 | -110 | -110 | -110 |
| Portland Trail Blazers +4.5 | -110 | -110 | -110 |
| Over 221.5 | -110 | -110 | -110 |
| Under 221.5 | -110 | -110 | -110 |
Minnesota Timberwolves
Last season, Minnesota finished with a 39-43 record against the spread, showing some inconsistency when it came to covering the number. As favorites of at least 3.5 points, the Timberwolves managed a 21-30 mark, falling short in several games where they were expected to dominate.
From a totals perspective, Minnesota leaned slightly toward high-scoring affairs, as 44 of their 82 contests went over the set line. On the moneyline, the Timberwolves were more reliable, winning 40 of 63 games when favored — a 63.5% success rate. They were especially strong in shorter-priced favorite roles, going 31-16 (66%) when listed at -166 or better.
Portland Trail Blazers
The Trail Blazers were one of the more dependable teams against the spread last season, finishing with a solid 46-36 record. They also performed well when cast as sizable underdogs, covering in 34 of 61 contests when getting 3.5 points or more.
In terms of totals, 40 of Portland’s games went over the projected line, reflecting a balanced mix of offensive surges and defensive lapses. The Blazers entered most matchups as underdogs — 69 in total — and managed to win 26 of those outright, a 37.7% success rate. When priced at +139 or longer on the moneyline, they secured victories in 19 of 57 games, good for just over 33%.
Minnesota Timberwolves vs. Portland Trail Blazers Betting Picks
Let’s get into the betting picks for the game.
Moneyline
Minnesota enters this matchup in a familiar position, having been favored on the moneyline 63 times last season and winning 40 of those games. When listed at odds of -178 or shorter, the Timberwolves were even more reliable, posting a 29-14 record — a strong 67.4% win rate. Based on the current moneyline, oddsmakers give Minnesota a 64.0% implied chance to come out on top.
Portland, meanwhile, was an underdog in 69 games last season and managed to win 26 of them, a 37.7% success rate. The Trail Blazers struggled more in deeper underdog spots, going 18-36 when priced at +148 or longer. Entering this contest, Portland’s implied probability to pull off the upset sits at 40.3%.
Against The Spread
ChatGPT said:
The Timberwolves averaged 114.3 points per game last season, just slightly above the 113.9 points per game that the Trail Blazers typically allowed. When Minnesota’s offense exceeded that number, the team went 27-17 against the spread and posted an impressive 33-11 overall record.
Portland found similar success when its offense clicked, going 33-12 ATS and 27-18 overall in contests where it scored more than 109.3 points. On the defensive end, Minnesota’s stinginess stood out — the Timberwolves were 26-16 ATS and 33-9 overall when holding opponents below that 110.9-point mark.
Statistically, Minnesota ranked 13th in scoring last season at 114.3 points per game, while Portland’s defense sat in the middle of the pack at 15th, surrendering 113.9 points on average. The Blazers, on the other hand, struggled more offensively, ranking 22nd in the league at 110.9 points per contest. Their opponent in this matchup, Minnesota, boasted the fifth-best defense in the NBA, allowing just 109.3 points per game. Overall, the Timberwolves outscored their opponents by a total of 410 points — an average margin of five per game — while Portland was outscored by 244 points, about three per outing.
Over/Under
ChatGPT said:
Minnesota’s implied total for this contest is set at 113 points, which comes in slightly lower than its average implied total of 114.5 from last season. The Timberwolves managed to score more than 113 points in 45 games during the 2024-25 campaign, showing their ability to surpass that benchmark regularly.
As for Portland, its offensive expectations have dipped noticeably. The Trail Blazers’ implied total sits at just 109 points for this matchup — a full 7.5 points below their 116.5-point average implied total from last season.
Below are some of the best options for your Minnesota Timberwolves vs. Portland Trail Blazers bets.
Best Betting Sites 