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- The Men’s NCAA Basketball Tournament has reached the Final Four stage
- The betting favorite to win the NCAA Tournament is the Duke Blue Devils.
- Duke is joined in the Final Four by Houston, Auburn, and Florida
- Below, we tell you who to get your money on in our latest NCAAB betting picks
We’ve nearly reached the end of the men’s NCAA Tournament, and what a finale it is set to be.
There are no Cinderella stories to speak of this year. For only the second time in history, all four No.1 seeds have advanced to the men’s Final Four.
This is also the first time it has happened since 2008.
The finals weekend will take place at the Alamodome in San Antonio, Texas. The action gets underway on Saturday when Auburn faces Florida. Tip-off is 6.09 pm.
The second match between Duke and Houston is also on Saturday, tip-off is at 8.49 pm, with the championship match taking place on Monday at 8.50 pm ET.
Before we get onto our Final Four betting picks, let’s first take a look at the latest NCAA Basketball Odds to win the 2025 National Championship match.
2025 Men’s NCAA Tournament Winner Betting
The top-rated college basketball betting sites favor a win for the Duke Blue Devils. Duke is +100 to win the 2025 championship match on the money line.
Florida is the second favorite at +300, with Houston at +400 and Auburn at +550.
More men’s NCAA Tournament winner odds are available on our basketball odds table. The odds are from our recommended college basketball betting partners.
| Men's Winner |  |  |  |
| Duke | +100 | +100 | +100 |
| Florida | +300 | +300 | +300 |
| Houston | +400 | +400 | +400 |
| Auburn | +550 | +550 | +550 |
Auburn vs. Florida
Saturday’s first semifinal is a showdown between the top two teams from the SEC.
The SEC regular-season champ Auburn (32-5) will face off against SEC tournament champion Florida (34-4).
- What: 2025 Men’s NCAA Tournament Final Four
- Who: Auburn Tigers vs. Florida Gators
- Where: Alamodome, San Antonio, Texas
- When: Saturday, April 5th, 2025
- Tip-Off: 6.09 pm ET
Auburn topped the SEC points table with a 15-3 record. The Florida Gators were second on 14-4.
Despite finishing the regular season in the runners-up position, the latest Final Four odds favor a win for the Gators.
- Auburn (+2.5) -110
- Florida (-2.5) -110
- Auburn +130
- Florida -150
- Over 159.5 -110
- Under 159.5 -110
The Gators booked their place in the Final Four with an 84-79 win over Texas Tech in the NCAA Tournament’s West Region final on Saturday.
Auburn was the last of the four No.1 seeds to book their spot in the Final Four.
The Tigers defeated Michigan State 70-64. A run of 17 unanswered points in the first half put them in control, and they never looked back.
The betting to win this match really is close, and we feel the bookies have called it right.
We are siding with Florida to win a close match. Our betting pick is Florida to win and cover the 2.5-point spread.
Duke vs. Houston
Onto the second match, and could the unbeaten since Thanksgiving weekend Houston (34-4) upset the betting favorites Duke (35-3)?
- What: 2025 Men’s NCAA Tournament Final Four
- Who: Duke Blue Devils vs. Houston Cougars
- Where: Alamodome, San Antonio, Texas
- When: Saturday, April 5th, 2025
- Tip-Off: 8.49 pm ET
The Blue Devils clinched their place in their 18th Final Four with an 85-65 win over the Alabama Crimson Tide in the East Region final.
Houston punched their ticket by defeating Tennessee 69-50 in the Midwest Region final.
The Cougars’ much-renowned defense did the trick, restricting the Vol’s shooters to just 15 points in the first half. The match was effectively over at that point.
- Houston (+5.5) -110
- Duke (-5.5) -110
- Houston +205
- Duke -250
- Over 136.5 -110
- Under 136.5 -110
Like the first semi-final, we also think one will be close.
Houston’s exceptional defensive play is edging us towards a bet on the Cougars with the spread, but we think Duke might sneak the match by a point or two.
Therefore, our betting pick for the match is for the Houston Cougars to win with the +5.5-point spread.
Our betting pick
Calling the winners of both Final Four matches is difficult. This makes calling the winner of the National Championship match even harder.
We see Florida getting to the final, but we believe that the winner of the championship match will come from the winner of the second semi-final.
We have gone for Houston to beat Duke with the spread. But it wouldn’t be a shock if the Blue Devils win the match by a couple of points.
Therefore our betting pick to win the National Championship match is whoever wins the Final Four showdown between the Blue Devils and the Cougars.
It may be worth backing the Cougars now at +400. Because if they beat Duke, they will probably start the final as the betting favorite.
See below our list of the best offshore sportsbooks for US bettors in 2025 and choose the one that suits you best:
Sports Betting Sites 