2022 March Madness – Sweet 16 Picks Day One – March 24, 2022

The field of 64 that began the hunt for the 2022 NCAA Basketball Championship has been whittled down to 16 teams as we get deeper into the 2022 edition of March Madness.

  • Sweet 16: March 24 & 25
  • Elite Eight: March 26 & 27
  • Final Four: April 2 at Caesars Superdome in New Orleans
  • National Championship: April 4 at Caesars Superdome in New Orleans

Last year’s champion, the Baylor Bears were eliminated in the second round by the No. 8 seeded University of North Carolina. Baylor was a No. 1 seed heading into this year’s tourney.

The team that fell to Baylor in the 2021 NCAA Basketball title game, the Gonzaga Bulldogs were the favorites to win the title in 2022. Gonzaga is still in the running as we head into the Sweet 16.

Before we look at the matchups for day one of the Sweet 16 which takes place on Thursday, March 24, check out the best sites for March Madness 2022 betting. Also, be sure to check out our NCAA College Basketball betting page for tips and advice on how to wager on NCAA basketball.

Arkansas (No. 4) vs. Gonzaga (No. 1)

  • Date & Location: Thursday, March 24 at Chase Center in San Francisco, CA
  • Time: 7:09 p.m. ET
  • How to Watch: CBS
TeamsBetOnlineSportsBetting.agBookMakerBetUS
Arkansas+335+335+345+340
Gonzaga-415-415-418-420

The Gonzaga Bulldogs have depth, power, and the ability to shoot from a high percentage from the floor. If the team was missing one of those components, the Arkansas Razorbacks would have a chance for an upset. Gonzaga is not missing anything.

Arkansas relies on its defense to create opportunities for them. With Gonzaga hitting from the field at a good rate, those opportunities will not be there.

Pick: Gonzaga to beat Arkansas.

GonzagaTo Beat Arkansas
star iconstar iconstar iconstar iconstar icon
-415
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Michigan (No. 11) vs. Villanova (No. 2)

  • Date & Location: Thursday, March 24 at AT&T Center in San Antonio, TX
  • Time: 7:29 p.m. ET
  • How to Watch: TBS
TeamsBetOnlineSportsBetting.agBookMakerBetUS
Michigan+180+180+180+180
Villanova-210-210-207-220

Michigan has had a good run this year in March Madness, beating No. 6 seed Colorado State and No. 3 seed Tennessee, but the Wolverines’ run is likely to end when it meets the Villanova Wildcats in the Sweet 16.

Michigan has been scoring in the tournament, but the Villanova defense is a beast the Wolverines have not had to deal with. When you couple the Wildcats defense with its ability to get off — and make — three-pointers — things don’t look good for Michigan in this matchup.

Pick: Villanova to beat Michigan.

Villanova To Beat Michigan
star iconstar iconstar iconstar iconstar icon
-210
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Texas Tech (No. 3) vs. Duke (No. 2)

  • Date & Location: Thursday, March 24 at Chase Center in San Francisco, CA
  • Time: 9:39 p.m. ET
  • How to Watch: CBS
TeamsBetOnlineSportsBetting.agBookMaker
Texas Tech-118-118-117
Duke-102-102+101

Texas Tech has been a shutdown team on defense. The Red Raiders limited Notre Dame to 32.7 percent shooting from the floor on their way to beating the Fighting Irish by a score of 59-53. It’s that defense that will carry Texas Tech over Duke.

That’s not to say Duke doesn’t have a chance. They do. The Blue Devils shot 57.1 from the field against the Michigan State Spartans in the second round and they have the kind of offensive power to give Texas Tech a tough game, but the defense of the Red Raiders limited their opponents to just 60.4 points per game during the 2022 NCAAB season.

Pick: Texas Tech to beat Duke.

Texas Tech To Beat Duke
star iconstar iconstar iconstar iconstar icon
-117
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Houston (No. 5) vs. Arizona (No. 1)

  • Date & Location: Thursday, March 24 at AT&T Center in San Antonio, TX
  • Time: 9:59 p.m. ET
  • How to Watch: TBS
TeamsBetOnlineSportsBetting.agBookMaker
Houston+111+111+112
Arizona-131-131-128

Arizona has not played like a No. 1 team during the 2022 NCAA tournament. The Wildcats have an 87-70 win over No. 16 Wright State and an 85-80 victory over No. 9 TCU. If Arizona did not buckle down during its days off before it faces the Houston Cougars, they could be in for an upset loss. I expect Arizona to look like a different team in the third round and come out more motivated and focused when they face Houston.

Pick: Arizona to beat Houston.

Arizona To Beat Houston
star iconstar iconstar iconstar iconstar icon
-131
Bet now

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Trent Reinsmith

Trent covers UFC and MMA for MTS. He currently covers MMA for MMA Junkie and Forbes. He has also written for Vice, Bloody Elbow, Fight! Magazine, UFC 360, and Narratively among others. He has been involved with MMA since he and some friends threw some money together to purchase the pay-per-view of UFC 1, and the rest is history.