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Week 12 of the college football season delivers a loaded slate featuring several powerhouse clashes. Alabama enters as a 6-point favorite against Oklahoma, while Georgia is laying the same margin against Texas in a pair of marquee Saturday showdowns that pit four of the winningest programs in FBS history against each other. Elsewhere, top-ranked Ohio State will face its first Big Ten test of the season against UCLA, with the Buckeyes heavily favored by 32.5 points according to the latest Week 12 odds.
- What? College Football Week 12
- Where? USA
- When? Saturday, November 15, 2026
Let’s delve into the week 12 betting picks.
Alabama vs. Oklahoma
Below are the odds from three of the best College Football betting sites.
| NCAAF |  |  |  |
| Oklahoma | +180 | +177 | +180 |
| Alabama | -220 | -205 | -220 |
| Oklahoma +6 | -115 | -112 | -115 |
| Alabama -6 | -105 | -108 | -105 |
| Over 46.0 | -110 | -110 | -110 |
| under 46.0 | -110 | -110 | -110 |
Alabama has clearly put its early-season setback in the rearview mirror. The Crimson Tide have reasserted their dominance as the class of the SEC, stringing together eight straight victories behind a balanced and efficient attack. Meanwhile, Oklahoma finds itself trending downward at the worst possible time, setting up what could be a ninth consecutive triumph for the Tide.
The Sooners’ biggest obstacle has been an inconsistent offense. Once considered a top-tier contender, Oklahoma has failed to maintain that billing as its production has stagnated. Entering Week 12, the Sooners sit just 78th nationally in total offense and 64th in scoring. Their defense has helped keep them competitive, but facing Alabama’s potent aerial assault will be an entirely different challenge.
Under new head coach Kalen DeBoer, the Crimson Tide have shifted toward a more pass-oriented identity — and it’s working. Alabama is averaging 279.6 yards through the air per game, ranking 15th in the nation, while their 32.8 points per contest place them among the top 25 in scoring. Expect that offensive rhythm to continue against an Oklahoma defense that has surrendered 708 passing yards and 61 total points in its last two outings.
Adding to the difficulty, this will mark the Sooners’ third road test in a four-game stretch, a daunting task against one of the country’s most complete teams. With Alabama surging toward the College Football Playoff picture, the Crimson Tide look well-positioned to roll once again in Tuscaloosa.
Notre Dame Fighting Irish vs. Pittsburgh Panthers
The Notre Dame Fighting Irish have quietly positioned themselves for a postseason push, methodically handling each opponent as they await movement in the College Football Playoff race. Entering Week 12 at No. 9 in the rankings, Notre Dame is targeting its eighth victory of the season, though a determined Pittsburgh Panthers squad won’t make things easy at Acrisure Stadium.
The Irish have been firing on all cylinders offensively during their current seven-game win streak. They sit 15th in the nation in total offense, averaging 466.1 yards per outing, and rank ninth in points scored. Their recent form has been especially impressive — Notre Dame has posted 36 points per game over its last four contests and topped 34 points in three of those matchups, fueled by an average of 471.8 total yards.
That offensive momentum should continue against a Pitt team that has struggled defensively in recent weeks. Once known for their toughness on that side of the ball, the Panthers have allowed 24.5 points per game over their last four, including a pair of outings where opponents topped 30. On the flip side, Pitt’s offense has been a pleasant surprise, scoring at least 30 points in each of its five games since October thanks to an efficient passing game.
The Panthers’ aerial attack will challenge Notre Dame’s most vulnerable area — its secondary. Given the offensive potential on both sides, this matchup shapes up as a high-scoring affair, making the over an appealing play.
Below are the best offshore sportsbooks for your College Football Week 12 bets.
Sports Betting Sites 