by
With Week 13 underway, programs enter the final stretch of the regular season with only two opportunities left to strengthen their cases for the College Football Playoff. Several matchups stand out on the board, including No. 11 Oklahoma laying 7.5 points against Missouri, No. 12 BYU favored by 2.5 over No. 25 Cincinnati, and No. 8 Oregon positioned as a 10-point favorite versus No. 17 USC. Let’s delve into the odds and see if we can find some value in the betting markets.
- What? College Football Week 13
- Where? USA
- When? Saturday, November 22, 2025
Oklahoma vs. Missouri
Below are the odds from three of the best College Football betting sites.
| NCAAF |  |  |  |
| Oklahoma | -310 | -305 | -305 |
| Missouri | +255 | +249 | +249 |
| Oklahoma -7.5 | -105 | -110 | -110 |
| Missouri +7.5 | -115 | -110 | -110 |
| Over 42 | Even | -110 | -110 |
| Under 42 | -120 | -110 | -110 |
A ranked SEC showdown awaits on Saturday as No. 8 Oklahoma welcomes No. 23 Missouri to Norman. The Sooners (8-2, 4-2 SEC) return home riding a surge of momentum after edging former No. 4 Alabama 23-21, which followed a victory over a higher-ranked Tennessee team the week prior. Missouri (7-3, 3-3 SEC) snapped its two-game slide in Week 12 with a commanding 49-27 win over Mississippi State. The Tigers also claimed last year’s SEC meeting between these programs, winning 30-23 on their home field.
The matchup kicks off at noon ET at Memorial Stadium, where Oklahoma is listed as a 7.5-point favorite and the total sits at 42. Statistically, these two boast the SEC’s strongest defensive units. The Sooners remain in full control of their path to the College Football Playoff, while Missouri has yet to cover in three tries as an underdog this season. Tigers quarterback Ahmad Hardy enters the weekend fresh off a 300-yard performance, but he’ll be up against an Oklahoma defense that ranks fourth nationally in rushing yards allowed at just 82.2 per game.
BYU vs. Cincinnati
The Week 13 slate also features a notable matchup at Nippert Stadium, where Cincinnati (7-3) is set to host BYU (9-1) on Saturday, November 22, 2025. Oddsmakers have the Bearcats opening as 2.5-point underdogs, with the total posted at 55.
BYU enters as a 2.5-point favorite, backed by a defense that has excelled in disruptive plays — the Cougars sit 11th nationally in sacks and 15th in interceptions. Cincinnati, meanwhile, has struggled to keep opponents off the scoreboard, ranking 84th in points allowed, which adds support to the idea that BYU covering the spread is a realistic expectation.
The total of 55 also draws interest. Both programs have surpassed 340 points on the season, placing Cincinnati 23rd and BYU 25th in scoring. With each offense proving consistently productive, a game that exceeds the posted total appears well within reach.
Oregon vs. USC
Oregon and USC are set to clash on Saturday, Nov. 22, with Autzen Stadium serving as the backdrop in Eugene. Oddsmakers have installed the Ducks as 9.5-point favorites, pricing Oregon at -400 on the moneyline and USC at +300. The total for this matchup sits at 59.5 points.
Both teams enter the weekend fighting to stay alive in the Big Ten title chase, each carrying a 6-1 conference mark. Their paths to the College Football Playoff, however, differ significantly. USC, already sitting on two losses, has no margin for error and must win out to stay in the conversation. Oregon can afford one more stumble and still remain viable in the CFP race.
USC is coming off a soggy but successful 26-21 win over Iowa, though the Trojans failed to cover the 6.5-point spread. Oregon, meanwhile, rolled past Minnesota 42-13 on Friday night, comfortably beating the 26.5-point number. While the Ducks enter in strong form, USC’s roster talent and coaching staff suggest this matchup could be tighter than the betting line implies.
See below the best offshore sportsbooks for your College Football week 13 bets. You can browse our comprehensive reviews to help determine the best option for your wagering requirements.
Sports Betting Sites 