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- What? College Football Week 9
- Where? USA
- When? Saturday, October 25, 2025
If you’re targeting ranked showdowns for your Week 9 college football wagers, the SEC is the place to start. The conference dominates the slate with three marquee clashes that will go a long way in determining its pecking order. Third-ranked Texas A&M faces No. 20 LSU as a narrow 2.5-point favorite, No. 8 Ole Miss meets No. 13 Oklahoma with the Rebels giving 5 points, and No. 10 Vanderbilt squares off against No. 15 Missouri as a 2.5-point underdog.
Beyond the SEC, several other high-profile matchups highlight the national picture. In the Big Ten, second-ranked Indiana is a heavy 25-point favorite against UCLA. Over in the ACC, No. 9 Miami is laying 30 points versus Stanford, while No. 11 BYU is giving three points in a tough Big 12 battle with Iowa State.
The Group of Five also features an intriguing opportunity for bettors. The American Athletic Conference’s South Florida Bulls, ranked 18th and the highest among non–Power Four programs, are listed as 4.5-point favorites against Memphis — a team looking to rebound after suffering its first loss of the season.
Texas A&M vs. LSU
Below are the odds from three of the best College Football betting sites.
| NCAAF |  |  |  |
| Texas A&M | -138 | -138 | -145 |
| LSU | +113 | +113 | +125 |
| Texas A&M -2.5 | -113 | -113 | -120 |
| LSU +2.5 | -107 | -107 | +100 |
| Over 47.5 | -111 | -111 | -110 |
| Under 47.5 | -109 | -109 | -110 |
This showdown features a Texas A&M squad riding a wave of momentum against an LSU team struggling to find its footing, with mounting pressure on its head coach after last week’s setback against Vanderbilt.
Whenever these two programs clash, though, recent form tends to mean little. History shows the home side usually comes out on top. That said, the Aggies look like the more balanced and disciplined team this season, consistently finding ways to prevail even when their offense has faced tough defensive units. While untimely penalties have occasionally disrupted promising drives or wiped out scores, A&M has generally maintained its rhythm and execution. LSU, on the other hand, has been unable to match its offensive expectations, though the Tigers’ defense continues to keep them in games.
Expect a relatively low-scoring battle that likely stays under 47.5 total points, with Texas A&M doing just enough to secure a narrow victory by fewer than seven points.
Check out our Lucky Rebel sportsbook review for much more information about this betting site.
Ole Miss vs. Oklahoma
The upcoming College Football battle between the Oklahoma Sooners and Ole Miss Rebels promises to be a defensive showdown. Oklahoma has allowed just 66 points this season, ranking 26th nationally. Ole Miss has surrendered 158 points, placing them 82nd. Both programs favor controlling the tempo through their defensive units. The signs point toward a game that may stay on the lower-scoring side.
Oklahoma has a history of games going under when totals are set at 50 or higher, posting a 13-15-1 record in such matchups at home over recent seasons. Meanwhile, Ole Miss’ 14th-ranked offense will face a stiff test against the Sooners’ elite sack-heavy defense, making it difficult for the Rebels to consistently move the ball. Last year’s encounter ended with only 40 points on the board, and given the current defensive trends, a similarly restrained scoring output seems likely. Ole Miss’ passing attack will be pressured heavily, potentially limiting big plays and points.
Factoring in these defensive strengths and historical patterns, the game projects to finish under the 54-point total. Both teams will lean on their defenses to control the pace and keep the contest tight throughout.
Missouri vs. Vanderbilt
This contest is shaping up to be a closely fought battle. Both quarterbacks are performing well and each team has shown strength on offense and defense. Missouri’s offense is capable of keeping the Tigers in contention, but Vanderbilt’s knack for producing explosive plays, particularly on their home field, gives them a slight edge. The game is likely to feature multiple shifts in momentum before a winner emerges.
UCLA vs. Indiana
Oddsmakers undoubtedly make Indiana a sizable favorite at home, and the reasoning is clear. While UCLA has shown signs of improvement that could allow them to stay close against a big spread, it’s difficult to envision the Hoosiers faltering with Mendoza leading the offense. Indiana is likely to control the pace from the start, forcing UCLA into a reactive role and relying heavily on Iamaleava’s rushing ability to try to keep up.
South Florida vs. Memphis
The Memphis Tigers come into this College Football matchup with an impressive home resume. They boast a perfect 3-0 record in their stadium this season. Even more encouraging for bettors, they have covered the spread in each of their last four home games, making them an attractive option against the spread at +4.5.
South Florida, despite being ranked 18th in the AP Poll, has struggled away from home, holding just a 2-1 record on the road. Their defense, ranked 84th nationally in points allowed, could have trouble containing Memphis’ high-powered offense, which sits 12th in scoring with 267 points this season. Memphis’ comfort in front of a home crowd gives them an advantage, especially as underdogs.
Trends following losses further bolster Memphis’ case. The Tigers have rebounded to win each of their last seven games after a defeat. With this combination of resilience and home-field strength, Memphis is poised to edge South Florida in what could be a high-scoring game, making them a smart pick at +4.5.
Below are the best offshore sportsbooks where you can place your College Football Week 9 bets.
Sports Betting Sites 