49ers blowout Seahawks: NFL Super Wild Card Weekend Picks

  • The San Francisco 49ers (13-4) are 10-point home favorites over the Seattle Seahawks (9-8) 
  • Pete Carroll has an 8-4 career record against Kyle Shanahan but has lost both games to his NFC West rival this season  
  • Super Wild Card Weekend kicks off from Levi’s Stadium on Saturday, January 14 at 4:30pm ET on FOX

It’s a great day to be a Seahawks fan. In addition to securing the No. 5 pick in the 2023 NFL Draft, Seattle clinched a playoff berth when the Lions defeated the Packers on Sunday night. Pete Carroll’s club will now head to San Francisco to face their NFC West rivals.

Will the red-rot 49ers defeat Seattle for the third time this season and roll into the NFC Divisional Round? Before we check the odds on this Saturday’s matchup, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022.

49ers vs Seahawks

BetOnline ReviewSpreadMoney LineTotal Points
Seattle Seahawks+10 (-106)+420Ov 42.5 (-110)
San Francisco 49ers-10 (-114)-525Un 42.5 (-110)

San Francisco surging

San Francisco has won 10 straight games after a 3-4 start to the season. Since replacing injured quarterback Jimmy Garoppolo, rookie Brock Purdy has thrown multiple pass touchdowns in six straight contests. George Kittle has been the biggest beneficiary, with seven spikes over the past four weeks. Christian McCaffrey is also a Comeback Player of the Year contender, racking up 746 rushing yards, 464 receiving yards and 10 combined TDs in his 11 games with the 49ers.

Kyle Shanahan’s club defeated the Seahawks 27-7 at home in Week 2 and secured a 21-13 victory in Seattle in Week 15. However, the offensive mastermind is only 4-8 all-time against Pete Carroll.

How good is Seattle?

Seattle notched its 10th playoff berth in 13 seasons under Pete Carroll and John Schneider. It was no doubt the sweetest of the ten for the coach-GM combo after shipping out longtime quarterback Russell Wilson for a haul of draft picks in the offseason. The Seahawks had lost five of six games after a scorching 6-3 start to the season, but squeaked into the playoffs with consecutive wins over the Jets and Rams.

In Sunday’s 19-16 victory over Los Angeles, Geno Smith set franchise records for passing yards (4,282), completions (399) and completion percentage (69.8). With a healthy Tyler Lockett and DK Metcalf, the journeyman QB will look to attack the Niners’ defense through the air.

San Francisco 49ersTo Cover Spread
Bet now
Seattle SeahawksTo Win
Bet now

San Francisco vs Seattle

San Francisco is a 10-point home favorite over Seattle and the over-under is set at 42.5 points. The UNDER would have hit comfortably in the teams’ previous meetings this year. However, both the 49ers (26.5) and Seahawks (23.9) rank in the top-10 in points scored per game. Kyle Shanahan’s club has also racked up more than 30 points in five of the past six contests.

The 49ers are even more impressive on the defensive side of the ball, holding opponents to a league-low 300.6 yards of offense per game. Defensive Player of the Year lock Nick Bosa led the NFL with 18.5 sacks in 2022. And DeMeco Ryan’s unit has enjoyed success versus Geno Smith this season. He’s averaged only 217.5 passing yards with a TD and an INT in the two losses.

Best Bet

There’s an old adage that it’s tough to beat a team three times in an NFL season. But it shouldn’t be too hard for Christian McCaffrey and Elijah Mitchell to run all over a Seahawks defense that has allowed eight different opponents to rush for at least 160 yards against them this season.

After a tense beginning, look for the 49ers to pull away in the 2nd half and cover the ten points.

Final Score Prediction: San Francisco 27, Seattle 13

49ers vs Seahawks-110
UNDER 42.5
Bet now

See below the top sportsbooks where you can wager online and choose the best one for you:




50% up to $1,000

Bet Now




100% up to $1,000

Bet Now




125% Sports Bonus - up to $2,500

Bet Now
Steve Starr

Steve is the quintessential American sports enthusiast. He has mastered the art of Sundays, devoting them to football, and barbecue parties. He proudly wears the hats of a good father, husband and a great dog owner. Aside from his decades of contributing to different top-tier sports publications, Steve has also found his niche on Twitter, where he publishes funny and relatable sports-related insights. When he's not busy tweeting, Steve loves to watch each game unfold live. He possesses an innate talent for finding humor in the sports world, appreciating both the thrilling moments and the comedic mishaps that make each event unique.

The most trusted Super Bowl betting sites Here!