49ers vs Chargers: NFL Sunday Night Football Week 10 Picks

  • The San Francisco 49ers (4-4) are touchdown favorites over the Los Angeles Chargers (5-3) in Week 10
  • Justin Herbert has averaged fewer than 6 yards per attempt in three straight starts
  • NBC’s Sunday Night Football kicks off from Levi’s Stadium in Santa Clara on November 13 at 8:20pm ET

Christian McCaffrey showed the football world why the 49ers mortgaged their future to acquire him, running, throwing and catching a touchdown in a virtuoso performance against the Rams in Week 8. Coming off a bye, the All-Pro running back had a chance to further immerse himself in Kyle Shanahan’s playbook ahead of this week’s Sunday Night Football matchup with the Chargers.

Before we check the odds for this all California encounter, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022.

49ers vs Chargers

BetOnline ReviewSpreadMoney LineTotal Points
Los Angeles Chargers+7.0 (-114)+255Ov 45 (-114)
San Francisco 49ers-7.0 (-106)-305Un 45 (-106)

Run CMC

Christian McCaffrey looked dangerous in the Niners’ offense in Week 8, rushing 18 times for 94 yards and a TD and catching eight passes for 55 yards and a score. One of just three players in NFL history with at least 1,000 rushing yards and 1,000 receiving yards in the same season, the 26-year-old gives Kyle Shanahan yet another versatile weapon. With CMC, George Kittle, Brandon Aiyuk and a healthy Deebo Samuel, San Francisco has emerged as a Super Bowl contender in the NFC.

The only question mark is Jimmy Garappolo. The journeyman quarterback threw for 235 yards and two TDs in a 31-14 victory over the Rams. And he has a chance to improve on those numbers against a Chargers defense permitting the third-most points per game (25.8) in the league.

Bolts have no juice

Injuries to Mike Williams and Keenan Allen have left Justin Herbert with a patchwork crew of pass catchers led by sophomore Josh Palmer and veteran tight end Gerald Everett. Luckily, he has one of the best safety blankets in the league in Austin Ekeler. The 27-year-old recorded his 10th career games with one-plus rushing and one-plus receiving TD in a 20-17 win over Atlanta in Week 9.

The victory improved Brandon Staley’s club to 5-3 on the season, but there is a catch. Los Angeles has played the third-easiest slate of opponents to date, whereas they have the NFL’s 10th most-difficult schedule remaining.

San Francisco 49ersTo Cover Spread
★★★★★
-7.0
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Los Angeles ChargersTo Win
★★★★★
+255
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49ers vs Chargers

San Francisco is a 7-point home favorite and oddsmakers have set the over-under at only 45 points. The 49ers defense ranks No. 1 in total yards allowed per game (285.8) and seventh in points allowed per game. This suggests the sledding could be tough for Joe Lombardi’s dink and dunk offense. Justin Herbert has averaged fewer than 6 yards per attempt in three consecutive starts. And Austin Ekeler will be up against the Niners’ league’s best run D (86.6 ypg).

With 8.5 sacks in seven games, Nick Bosa’s odds to win NFL Defensive Player of the Year (+650) trail only Micah Parsons (-210). Look for him and the rest of DeMeco Ryans’ league-best unit to wreak havoc on Sunday night.

Best Bet

The Chargers are in the mix for a playoff spot in the AFC despite being mediocre on offense and defense throughout the season. However, this is the perfect showcase for head coach Brandon Staley to be exposed as a fraud.

With McCaffrey added to what could be an unstoppable offense, the 49ers will come off their bye and blowout Los Angeles.

Final Score Prediction: San Francisco 34, Chargers 20

49ers vs Chargers-110
★★★★★
OVER 45
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

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