2022 NFL Season Opener: Rams vs. Bills Picks

  • The Buffalo Bills are 2.5-point road favorites over the Super Bowl champion Los Angeles Rams
  • Josh Allen’s club opens the year as +600 title favorites after a heartbreaking loss to the Chiefs in the AFC Divisional Round
  • The 2022 NFL regular season kicks off from SoFi Stadium on Thursday, September 8 at 8:30 pm ET

The Bills were just 13 seconds away from advancing to the AFC Championship Game before Kansas City’s miraculous comeback led to a horrifying 42-36 overtime defeat. With Josh Allen’s otherworldly performance still fresh in the minds of football fans, Buffalo opens the 2022 NFL season as +600 Super Bowl favorites.

Sean McDermott’s ball club will be tested immediately in the season opener against the Super Bowl 56 champion Los Angeles Rams. Before we check the odds on the game, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022

Rams vs. Bills

BetOnlineSpreadMoney LineTotal Points
Buffalo Bills-2.5 (-110)-135Ov 53 (-110)
Los Angeles Rams+2.5 (-110)+115Un 53 (-110)

Circle the wagons

Buffalo is a 2.5-point road favorite over Los Angeles on Thursday night. The Bills handed future Hall-of-Famer Von Miller a massive deal in free agency, upgraded their offensive line, and added corner Kaiir Elam and running back James Cook in the first two rounds of the 2022 NFL Draft.

However, the loss of offensive coordinator Brian Daboll could loom large if new OC Ken Dorsey is not as pass happy as his predecessor. The team’s star corner Tre’Davious White will also start the season on the reserve/PUP list. 

Super Bowl repeat?

Three-time Defensive Player of the Year Aaron Donald and head coach Sean McVay floated retirement rumors before predictably securing huge paydays and returning to Hollywood. Concerns about Matthew Stafford’s elbow are also fading as the season draws near. That means the Rams’ passing game should thrive if Allen Robinson can turn back the clock with improved quarterback play.

The bigger question mark is the ground game, with Cam Akers looking to become the first running back to ever return to form after suffering an Achilles tear.

Buffalo BillsTo Cover Spread
★★★★★
-2.5
Bet now
Los Angeles RamsTo Win
★★★★★
+115
Bet now

Rams vs. Bills

The oddsmakers expect a lot of scoring on opening night, setting the over/under at a robust 53 points. Josh Allen is the only player in NFL history with at least 100 touchdown passes and 30 rushing TDs over his first four NFL seasons. He’ll be looking to hook up with Stefon Diggs and potential breakout star Gabe Davis.

Meanwhile, it’s fair to wonder if Matthew Stafford will be even better in his second year under Sean McVay. Before going on to win the Super Bowl, the 34-year-old finished the regular season with 4,886 passing yards and 41 TDs.

Best Bet

While Sean McVay and the Rams spent the offseason enjoying the splendors of their Super Bowl victory, Sean McDermott’s Bills head into the season focused on the task at hand.

We like Buffalo to cover the 2.5 points in a lower-scoring battle than most anticipate.

Final Score Prediction: Buffalo 27, Rams 21

Rams vs Bills-110
★★★★★
UNDER 53
Bet now

 

See below the top sportsbooks where you can wager online and choose the best one for you:

#1

★★★★★

Bonus

50% up to $1,000

Bet Now

#2

★★★★★

Bonus

100% up to $1,000

Bet Now

#3

★★★★★

Bonus

125% Sports Bonus - up to $2,500

Bet Now
Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

Check how to bet on sports online Here!