2022 NFL Week 1 Sunday Game Picks

  • BetOnline has lines, spreads and over/unders for all 14 games on Sunday, September 11
  • Tom Brady’s Buccaneers are 1-point road favorites over the Dallas Cowboys on Sunday Night Football
  • Baker Mayfield and the Panthers host the Cleveland Browns in the first ‘revenge game’ of the 2022 NFL season

Everything is about to change. On Sunday, all the prevailing media narratives and fantasy expert consensus will be blown to smithereens in one action-packed day of football.

Let’s take a gander at Week 1’s best games and pick some winners. Before we check the odds, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022.

NFL Week 1 – Sunday, Sept. 11

BetOnlineSpreadMoney LineTotal Points
Baltimore Ravens-7 (-105)-290Un 44½ (-105)
New York Jets+7 (-115)+245Ov 44½ (-115)
New Orleans Saints-5½ (-110)-220Un 42½ (-110)
Atlanta Falcons+5½ (-110)+190Ov 42½ (-110)
New England Patriots+3 (-107)+138Ov 47 (-110)
Miami Dolphins-3 (-113)-158Un 47 (-110)
Cleveland Browns+2 (-105)+120Ov 41½ (-110)
Carolina Panthers-2 (-115)-140Un 41½ (-110)
Pittsburgh Steelers+6.5 (-110)+220Ov 44½ (-110)
Cincinnati Bengals-6.5 (-110)-260Un 44½ (-110)
San Francisco 49ers-7 (-105)-290Ov 41½ (-105)
Chicago Bears+7 (-115)+245Un 41½ (-115)
Philadelphia Eagles-4 (-110)-195Ov 49 (-110)
Detroit Lions+4 (-110)+170Un 49 (-110)
Indianapolis Colts-8½ (-108)-375Ov 46 (-115)
Houston Texans+8½ (-112)+305Un 46 (-105)
Jacksonville Jaguars+3 (-107)+145Ov 44 (-110)
Washington Commanders-3 (-113)-165Un 44 (-110)
Kansas City Chiefs-4½ (-110)-205Ov 53½ (-110)
Arizona Cardinals+4½ (-110)+175Un 53½ (-110)
Las Vegas Raiders+3 (+105)+160Ov 52 (-115)
Los Angeles Chargers-3 (-125)-180Un 52 (-105)
Green Bay Packers-1 (-117)-125Ov 48 (-110)
Minnesota Vikings+1 (-103)+105Un 48 (-110)
New York Giants+5½ (-110)+215Ov 43.5 (-115)
Tennessee Titans-5½ (-110)-255Un 43.5 (-105)
Tampa Bay Buccaneers-1 (-115)-120Ov 50½ (-115)
Dallas Cowboys+1 (-105)+100Un 50½ (-105)

Panthers (-2) over Browns

Even more bizarre than the quarterback plan in Seattle is what the Browns have maneuvered themselves into this season. Jacoby Brissett did not look remotely like an NFL starter last year. That leaves Nick Chubb and the offensive line to do all the heavy lifting. Baker Mayfield reportedly said, “I’m going to f–k them up” and after all the Deshaun Watson stuff, who wouldn’t like to see that on opening weekend?

With a healthy Christian McCaffrey, an underrated star in D.J. Moore and a promising young defense, the Panthers are primed to get off to a good start in Carolina.

Raiders (+3) over Chargers

Led by promising third-year quarterback Justin Herbert, the Chargers are once again a fashionable pick among NFL media types. But let’s not overlook Derek Carr and the Raiders, who snuck into the playoffs last season with a 35-32 overtime Week 17 win over Los Angeles. With the additions of coach Josh McDaniels, receiver Davante Adams, defensive end Chandler Jones and DC Patrick Graham, Las Vegas is being overlooked in the AFC West.

Carolina PanthersTo Cover Spread
★★★★★
-2.0
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Las Vegas RaidersTo Win Outright
★★★★★
+160
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Chiefs (-4.5) over Cardinals

Patrick Mahomes versus Kyler Murray is by far the week’s most enticing QB matchup – with the highest over/under (53.5) of opening weekend. Arizona reeled off seven-straight victories to open last season, but Andy Reid will have a few tricks up his sleeve in a new-look Chiefs offense. Kansas City will usher in a new era by doing something they rarely achieved in 2021… covering the spread.

Jaguars (+3) over Commanders

Sophomore QB Trevor Lawrence upgraded coaches from Urban Meyer to Doug Pederson, who will be coaching his first game for the Jaguars against his former student Carson Wentz. While the buzz out of Jacksonville has been positive all summer, the Commanders are presiding over a looming dumpster fire. Wentz struggled with accuracy throughout camp, rookie running back Brian Robinson was shot in an armed robbery, and defensive end Chase Young is on the PUP list.

Cowboys (+1) over Buccaneers

Nobody seems to think Dallas will be any good this season with questions surrounding their offensive line, Mike McCarthy’s job security and Ezekiel Elliott’s decline. However, the Cowboys have more continuity than Tampa Bay, who has a new coach in Todd Bowles, injuries at wide receiver, and offensive line questions of their own.

In the first prime-time surprise of the 2022 NFL season, we like America’s Team and Micah Parsons over 45-year-old Tom Brady and the Buccaneers.

Jacksonville JaguarsTo Win Outright
★★★★★
+145
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

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