Steve Starr
- BetOnline has lines, spreads, and over/unders for all 13 games on Sunday, September 18
- Tom Brady’s Buccaneers are 3-point road favorites despite losing four-straight regular season games to the Saints
- Aaron Rodgers has a 23-5 career record against the Chicago Bears
After a flurry of Week 1 upsets knocked everybody out of their Eliminator/Survivor pools, NFL oddsmakers seem to be tempting bettors with a number of huge points spreads in Week 2. The Broncos, Packers, Rams, and 49ers are all 10-point favorites despite losing their season openers.
Let’s examine Week 2’s best games and pick some winners. Before we check the odds, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022.
NFL Week 2 – Sunday, Sept. 18
 | Spread | Money Line | Total Points |
| Miami Dolphins | +3.5 (-108) | +165 | Un 45 (-105) |
| Baltimore Ravens | -3.5 (-112) | 190 | Ov 45 (-115) |
| New York Jets | +6 (-110) | +215 | Un 40 (-110) |
| Cleveland Browns | -6 (-110) | -255 | Ov 40 (-110) |
| Washington Commanders | +1 (+106) | +115 | Un 49.5 (-110) |
| Detroit Lions | -1 (-126) | -135 | Ov 49.5 (-110) |
| Indianapolis Colts | -4 (-110) | -205 | Un 46 (-115) |
| Jacksonville Jaguars | +4 (-110) | +175 | Ov 46 (-105) |
| Tampa Bay Buccaneers | -3 (+100) | -150 | Un 44 (-115) |
| New Orleans Saints | +3 (-120) | +130 | Ov 44 (-105) |
| Carolina Panthers | +1 (+106) | +115 | Un 43 (-110) |
| New York Giants | -1 (-126) | -135 | Ov 43 (-110) |
| New England Patriots | -1 (-110) | -118 | Un 40 (-110) |
| Pittsburgh Steelers | +1 (-110) | -102 | Ov 40 (-110) |
| Atlanta Falcons | +10.5 (-110) | +430 | Un 47 (-110) |
| Los Angeles Rams | -10.5 (-110) | -550 | Ov 47 (-110) |
| Seattle Seahawks | +10 (-115) | +360 | Un 42.5 (-110) |
| San Francisco 49ers | -10 (-105) | -450 | Ov 42.5 (-110) |
| Cincinnati Bengals | -7.5 (-120) | -360 | Un 42.5 (-110) |
| Dallas Cowboys | +7.5 (+100) | +290 | Ov 42.5 (-110) |
| Houston Texans | +10 (-110) | +360 | Un 46 (-115) |
| Denver Broncos | -10 (-110) | -450 | Ov 46 (-105) |
| Arizona Cardinals | +6 (-115) | +200 | Un 51.5 (-110) |
| Las Vegas Raiders | -6 (-105) | -240 | Ov 51.5 (-110) |
| Chicago Bears | +10 (-115) | +350 | Un 42.5 (-110) |
| Green Bay Packers | -10 (-105) | -430 | Ov 42.5 (-110) |
Saints (+3) over Buccaneers
New Orleans has won all four regular-season meetings with the Buccaneers over the past two seasons. Dennis Allen’s defense embarrassed Tom Brady on two of those occasions, including a 9-0 shutout last December that may have cost the golden boy his fourth NFL MVP award. Tampa Bay will also be without receiver Chris Godwin after already struggling to score against the Cowboys in Week 1.
Meanwhile, Jameis Winston and the Saints are coming off a miraculous 16-point comeback on the Falcons (who else?). After recording five catches for 57 yards and two touchdowns in the 27-26 victory, receiver Michael Thomas looks to continue his comeback story in the Big Easy this Sunday.
Michael Thomas is BACK ⚜️
(📸 @Saints) pic.twitter.com/vK6TaGTKcQ
— PFF (@PFF) September 11, 2022
Steelers (+1) over Patriots
While the Steelers will be missing T.J. Watt, they might not actually need the 2022 NFL Defensive Player of the Year to stop New England’s Matt Patricia/Joe Judge-led offense. The Patriots committed three turnovers and scored only seven points in a road loss to Miami. Now they head to Pittsburgh to face a defense that picked off Joe Burrow four times in a 23-20 victory.
Seahawks (+10) over 49ers
The Seahawks might seem primed for a letdown after an emotional 17-16 win over Russell Wilson and the Broncos on Monday Night Football. However, Pete Carroll has owned Kyle Shanahan of late, winning their last four meetings. There’s also no denying that Geno Smith is a more professional quarterback than Trey Lance at this juncture of their respective careers. While better weather should help the 49ers’ sophomore starter on Sunday, Seattle’s young defense and strong run game will keep things close.
ICYMI: #Seahawks’ Pete Carroll lost Russell Wilson but might have won back his old team: Sando’s Pick Sixhttps://t.co/9LkWeqw0Cv
— Mike Sando (@SandoNFL) September 14, 2022
Raiders (-6.0) over Cardinals
Kliff Kingsbury’s Cardinals are a leading contender for a pending dumpster fire following a 44-21 annihilation at the hands of the Chiefs. While Patrick Mahomes has embarrassed a lot of teams in his young career, Arizona was overmatched at every phase of the game. Derek Carr and Davante Adams should have no problem continuing where they left off in Week 1 (10 connections for 141 yards and a TD) in what will be Josh McDaniel’s first win as a Las Vegas Raider.
Packers (-10) over Bears
Aaron Rodgers is 23-5 all-time against the Bears, including playoff games. The 38-year-old has also won each of the last four matchups by at least 10 points, memorably screaming “I still own you” to Bears fans after running a game-clinching six-yard touchdown into the endzone last October.
See below the top sportsbooks where you can wager online and choose the best one for you:
