2022 NFL Week 2 Sunday Game Picks

  • BetOnline has lines, spreads, and over/unders for all 13 games on Sunday, September 18
  • Tom Brady’s Buccaneers are 3-point road favorites despite losing four-straight regular season games to the Saints
  • Aaron Rodgers has a 23-5 career record against the Chicago Bears

After a flurry of Week 1 upsets knocked everybody out of their Eliminator/Survivor pools, NFL oddsmakers seem to be tempting bettors with a number of huge points spreads in Week 2. The Broncos, Packers, Rams, and 49ers are all 10-point favorites despite losing their season openers.

Let’s examine Week 2’s best games and pick some winners. Before we check the odds, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022.

NFL Week 2 – Sunday, Sept. 18

BetOnlineSpreadMoney LineTotal Points
Miami Dolphins+3.5 (-108)+165Un 45 (-105)
Baltimore Ravens-3.5 (-112)190Ov 45 (-115)
New York Jets+6 (-110)+215Un 40 (-110)
Cleveland Browns-6 (-110)-255Ov 40 (-110)
Washington Commanders+1 (+106)+115Un 49.5 (-110)
Detroit Lions-1 (-126)-135Ov 49.5 (-110)
Indianapolis Colts-4 (-110)-205Un 46 (-115)
Jacksonville Jaguars+4 (-110)+175Ov 46 (-105)
Tampa Bay Buccaneers-3 (+100)-150Un 44 (-115)
New Orleans Saints+3 (-120)+130Ov 44 (-105)
Carolina Panthers+1 (+106)+115Un 43 (-110)
New York Giants-1 (-126)-135Ov 43 (-110)
New England Patriots-1 (-110)-118Un 40 (-110)
Pittsburgh Steelers+1 (-110)-102Ov 40 (-110)
Atlanta Falcons+10.5 (-110)+430Un 47 (-110)
Los Angeles Rams-10.5 (-110)-550Ov 47 (-110)
Seattle Seahawks+10 (-115)+360Un 42.5 (-110)
San Francisco 49ers-10 (-105)-450Ov 42.5 (-110)
Cincinnati Bengals-7.5 (-120)-360Un 42.5 (-110)
Dallas Cowboys+7.5 (+100)+290Ov 42.5 (-110)
Houston Texans+10 (-110)+360Un 46 (-115)
Denver Broncos-10 (-110)-450Ov 46 (-105)
Arizona Cardinals+6 (-115)+200Un 51.5 (-110)
Las Vegas Raiders-6 (-105)-240Ov 51.5 (-110)
Chicago Bears+10 (-115)+350Un 42.5 (-110)
Green Bay Packers-10 (-105)-430Ov 42.5 (-110)

Saints (+3) over Buccaneers

New Orleans has won all four regular-season meetings with the Buccaneers over the past two seasons. Dennis Allen’s defense embarrassed Tom Brady on two of those occasions, including a 9-0 shutout last December that may have cost the golden boy his fourth NFL MVP award. Tampa Bay will also be without receiver Chris Godwin after already struggling to score against the Cowboys in Week 1.

Meanwhile, Jameis Winston and the Saints are coming off a miraculous 16-point comeback on the Falcons (who else?). After recording five catches for 57 yards and two touchdowns in the 27-26 victory, receiver Michael Thomas looks to continue his comeback story in the Big Easy this Sunday.

Steelers (+1) over Patriots

While the Steelers will be missing T.J. Watt, they might not actually need the 2022 NFL Defensive Player of the Year to stop New England’s Matt Patricia/Joe Judge-led offense. The Patriots committed three turnovers and scored only seven points in a road loss to Miami. Now they head to Pittsburgh to face a defense that picked off Joe Burrow four times in a 23-20 victory.

Pittsburgh SteelersTo Cover Spread
★★★★★
+1.0
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New Orleans SaintsTo Win Outright
★★★★★
+130
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Seahawks (+10) over 49ers

The Seahawks might seem primed for a letdown after an emotional 17-16 win over Russell Wilson and the Broncos on Monday Night Football. However, Pete Carroll has owned Kyle Shanahan of late, winning their last four meetings. There’s also no denying that Geno Smith is a more professional quarterback than Trey Lance at this juncture of their respective careers. While better weather should help the 49ers’ sophomore starter on Sunday, Seattle’s young defense and strong run game will keep things close.

Raiders (-6.0) over Cardinals

Kliff Kingsbury’s Cardinals are a leading contender for a pending dumpster fire following a 44-21 annihilation at the hands of the Chiefs. While Patrick Mahomes has embarrassed a lot of teams in his young career, Arizona was overmatched at every phase of the game. Derek Carr and Davante Adams should have no problem continuing where they left off in Week 1 (10 connections for 141 yards and a TD) in what will be Josh McDaniel’s first win as a Las Vegas Raider.

Packers (-10) over Bears

Aaron Rodgers is 23-5 all-time against the Bears, including playoff games. The 38-year-old has also won each of the last four matchups by at least 10 points, memorably screaming “I still own you” to Bears fans after running a game-clinching six-yard touchdown into the endzone last October.

Green Bay PackersTo Cover Spread
★★★★★
-10.0
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

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