Chiefs vs Bills: NFL Sunday Week 6 Picks

  • The Kansas City Chiefs (4-1) are 3-point home underdogs to the Buffalo Bills (4-1)
  • Josh Allen (+170) and Patrick Mahomes (+425) are the current favorites to win 2022 NFL MVP award
  • The Week 6 game on CBS will kick off from Arrowhead Stadium on Sunday, October 16 at 4:25pm ET

It’s the rematch we’ve all been waiting for. In Week 6, Josh Allen and the Bills will head to Arrowhead Stadium, the site of their infamous 42-36 overtime-loss to Patrick Mahomes and the Chiefs in last year’s AFC Divisional playoff game.

Before we check the odds on the contest between the two NFL superpowers, here’s where you can find the best Super Bowl betting tips and the top betting sites for NFL football in 2022.

Chiefs vs Bills

BetOnline ReviewSpreadMoney LineTotal Points
Buffalo Bills-3.0 (-110)-151Ov 54 (-110)
Kansas City Chiefs+3.0 (-110)+131Un 54 (-110)

Mahomes vs Allen

Patrick Mahomes is a home underdog for the first time in his six-year career, as the visiting Bills opened as 3-point road favorites at Arrowhead. This could be good news for the Chiefs, who are 6-2 outright as underdogs in Mahomes’ starts. Then again, it’s hard to bet against a Buffalo team coming off a 38-3 destruction of the Steelers.

Josh Allen already had 348 yards and four touchdowns at halftime of the Week 5 win. Sean McDermott wisely put him on ice for the second half. But he was easily on pace to break the single-game record for passing yardage (554 yards) that Norm Van Brocklin has held since 1951,

Bills look for revenge

Buffalo’s season has ended in the playoffs at the hands of the Chiefs each of the past two seasons. However, the Bills did secure a 38-20 victory over KC in Arrowhead last October.

Last January’s AFC Divisional Round loss was particularly painful for Sean McDermott’s club. Patrick Mahomes famously led his team 44 yards in the final 13 seconds of regulation to set up a game-tying field goal. Kansas City then got the ball to start overtime, winning the game 42-36 without giving Josh Allen another chance.

Buffalo BillsTo Cover Spread
★★★★★
-3.0
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Kansas City ChiefsTo Win
★★★★★
+131
Bet now

Chiefs vs Bills

Kansas City overcame a 17-point deficit to Las Vegas to secure a 30-29 victory on Monday Night Football. Mahomes tossed all four touchdowns to Travis Kelce.

Containing the Chiefs’ star tight end will be paramount for Buffalo. Kelce had eight receptions for 96 yards and a score in last January’s Divisional Game triumph. He also racked up 13 catches for 118 yards and two touchdowns in the AFC Championship win over the Bills two seasons ago. Of course, Tyreek Hill was still around for both of those victories.

The return of safety Jordan Poyer would be huge for a Bills squad that lost safety Micah Hyde for the season and is still without star corner Tre’Davious White. However, Leslie Frazier’s defense has been amongst the NFL’s best this year.

Best Bet

Buffalo is a three-point road favorite in Kansas City and the game total is a sky-high 54 points – a total that the teams easily exceeded in each of their past three matchups.

Mahomes will find a way to generate offense, but he is bringing a knife to a gun fight in this one.  While KC’s new acquisitions, JuJu Smith-Schuster and Marquez Valdes-Scantling, have disappointed, Allen can call on Stefon Diggs, Gabe Davis, Isaiah McKenzie, rookie receiver Khalil Shakir and tight end Dawson Knox in the passing game.

With a day’s more rest and infinitely more weapons, the Bills will win and cover the spread.

Final Score Prediction: Buffalo 34, Chiefs 24

Chiefs vs Bills-110
★★★★★
OVER 54
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

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