NFL Week 15 Odds: Game Lines, Picks and Predictions

  • Go to BetOnline or Bovada for updated NFL Week 15 odds – spreads, moneylines, over/unders and more
  • Patrick Mahomes is 3-0 in indoor starts for his career and the Chiefs will enter the Superdome as three-point road favorites over the Saints 
  • The Seahawks are six-point favorites over a Washington Football Team that may be forced to start sophomore QB Dwayne Haskins

While Week 15 of the NFL season doesn’t offer many marquee matchups aside from Chiefs/Saints on Sunday afternoon, the games will go a long way towards crystallizing the playoff picture in both conferences.

Let’s take a look at the updated lines for the full slate and make some winning picks against the spread. And before you place your bets, make sure you’re getting the best value from your sportsbook.


BetOnlineSpreadMoney LineTotal
Los Angeles Chargers+3½ (-110)+165Ov 53 (-110)
Las Vegas Raiders-3½ (-110)-190Un 53 (-110)
Buffalo Bills-7 (+105)-275Ov 50 (-104)
Denver Broncos+7 (-125)+230Un 50 (-116)
Carolina Panthers+10 (-135)+330Ov 51.5 (-110)
Green Bay Packers-10 (+115)-410Un 51.5 (-110)
Houston Texans+7 (-110)+270Ov 51 (-110)
Indianapolis Colts-7 (-110)-325Un 51 (-110)
Tampa Bay Buccaneers-6 (-110)-255Ov 50.5 (-110)
Atlanta Falcons+6 (-110)+215Un 50.5 (-110)
New England Patriots+1 (+105)+120Ov 41.5 (-110)
Miami Dolphins-1 (-125)-140Un 41.5 (-110)
Seattle Seahawks-6 (-110)-250Ov 44.5 (-111)
Washington Football Team+6 (-110)+210Un 44.5 (-109)
Chicago Bears+3 (+105)+160Ov 46 (-117)
Minnesota Vikings-3 (-125)-180Un 46 (-103)
Jacksonville Jaguars+14 (-119)+640Ov 46.5 (-110)
Baltimore Ravens-14 (-101)-900Un 46.5 (-110)
San Francisco 49ers-3 (+110)-140Ov 45 (-110)
Dallas Cowboys+3 (-130)+120Un 45 (-110)
New York Jets+17 (-110)+900Ov 44 (-105)
Los Angeles Rams-17 (-110)-1700Un 44 (-115)
Philadelphia Eagles+7 (-130)+227Ov 49.5 (-110)
Arizona Cardinals-7 (+110)-267Un 49.5 (-110)
Kansas City Chiefs-3 (-115)-165Ov 51.5 (-110)
New Orleans Saints+3 (-105)+145Un 51.5 (-110)
Cleveland Browns-4 (-105)-190Ov 45.5 (-110)
New York Giants+4 (-115)+165Un 45.5 (-110)
Pittsburgh Steelers-13 (+100)-700Ov 40.5 (-105)
Cincinnati Bengals+13 (-120)+520Un 40.5 (-115)


Jon Gruden fired defensive coordinator Paul Guenther after his unit gave up 44 points in a Week 14 defeat to the Colts. With three losses in their last four times out, the 7-6 Raiders will now have to run the table against the Chargers, Dolphins, and Broncos to make the playoffs.

Given the circumstances, Las Vegas should have more urgency than Los Angeles on Thursday night, but we believe the Bolts’ 20-17 victory over the Falcons will provide a shot in the arm after a miserable season filled with agonizing losses. Chargers (+3.5 at Bovada)

At 8-5, the Dolphins also have to win out to earn a postseason berth. Unfortunately, injuries and the COVID list have wiped out their entire running back room and receiving corps. New England’s offense has looked downright ugly all year, but given that Bill Belichick’s defense will have had 10 days to prepare for this one, we expect the Pats to play spoiler to Miami for a change. Patriots (+1.0 and +105 money line at BetOnline

After their Chase Young-led defense forced eight turnovers in the past four games (all wins), Washington is now in the driver’s seat in the NFC East. Coach of the Year frontrunner Ron Rivera is reportedly optimistic that Alex Smith will suit up this week despite leaving Sunday’s contest with a calf injury, but there is a chance that Dwayne Haskins starts at quarterback. That reason alone is worth betting on Russell Wilson’s Seahawks covering the six points. Seattle (-6.0 at Bovada)

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Prior to their surprising 24-21 loss to Philadelphia on Sunday, the Saints had won five straight while allowing a total of 44 points (quick math: that’s under nine per game), so they certainly have the defense to slow down Patrick Mahomes, who’s coming off an uncharacteristic three-interception performance against Miami.

However, Mahomes is 3-0 in indoor starts for his career with a 91.8 passer rating and Kansas City has won 22 of its past 23, postseason included. Billed as a potential Super Bowl preview, it’s difficult to see Taysom Hill scoring enough points to keep up with the Chiefs superstar. Especially when another subpar performance by Mahomes could swing the MVP race to Aaron Rodgers. Chiefs (-3.0 at BetOnline)

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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

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