Steve Starr
- BetOnline has Buffalo as 6-point road chalk versus Tennessee on Monday Night Football
- Josh Allen and the Bills are Super Bowl favorites after a decisive 38-20 defeat of Patrick Mahomes and the Chiefs
- Oddsmakers have set the game total for this Week 6 matchup at 53.5 points
Is Buffalo poised for a letdown on Monday Night Football after dominating the Chiefs in primetime, or are they out for revenge against a Tennessee club that blew them out 42-16 in Week 5 of last season?
Coming off a 37-19 victory over the winless Jaguars on Sunday, the 3-2 Titans opened as a 6-point home underdog to the 4-1 Bills. Before we look at the line for the last game on the Week 6 slate, be sure to check out our free tips and advice for betting on NFL football games and Super Bowl futures.
Monday Night Football
 | Spread | Money Line | Total Points |
| Buffalo Bills | -6.0 (-108) | -260 | Ov 53.5 (-113) |
| Tennessee Titans | +6.0 (-112) | +220 | Un 53.5 (-107) |
Titans vs Bills
Buffalo is 6-point road favorite in Tennessee on Monday night. Josh Allen passed for 315 yards and three touchdowns in a 38-20 stomping of Kansas City, adding 59 yards and a score on the ground for good measure. The 2021 NFL MVP frontrunner should be salivating at the thought of Stefon Diggs, Emmanuel Sanders and Dawson Knox running wild against a poor Titans secondary that couldn’t even shutdown the Jets in Week 4.
Tennessee’s game plan will be what it always is – feed Derrick Henry. The two-time rushing champion is once again leading the NFL in rushing yards (640) and rushing TDs (7) after rumbling for 130 yards and three touchdowns in a 37-19 win at Jacksonville on Sunday.
How dominant has Derrick Henry been?
Most Rush Yards over 40-game stretch NFL History:
Henry 4,792 (2018-21)
Jim Brown 4,759 (1963-65)
O.J. Simpson 4,739 (1972-75)
Terrell Davis 4,597 (1996-98)
Eric Dickerson 4,594 (1984-86)Absolute FORCE pic.twitter.com/it4sl6DpaG
— NFL on CBS 🏈 (@NFLonCBS) October 10, 2021
Sean McDermott has suggested that standout linebacker Matt Milano might return from injury on Monday – which will help contain Henry.
Bills defensive end Greg Rousseau, who was named the AFC Defensive Player of the Week after registering a sack, five tackles and a pick against KC, is also poised for a big week against Ryan Tannehill, who has been sacked a league-leading 20 times.
MNF Best Bets
Bet the UNDER on 53.5. While we have full confidence that Buffalo will be able to score at will, we’re skeptical that Tennessee’s offense will be able to keep pace with the Bills as it’s built to play in front with the lead. The Titans haven’t faced a competent defense since falling to the Cardinals 38-13 in the season opener, and coming from behind against the Bills will prove much harder than it was versus Seattle in Week 2.
Josh Allen: 137.6 Passer Rating on throws 10+ yards downfield
Best in the NFL 🚀 pic.twitter.com/aZu8aHR93Q
— PFF Fantasy Football (@PFF_Fantasy) October 13, 2021
Bills to cover 6-point spread. Buffalo is a tier-one Super Bowl contender that is better than the Titans on both sides of the ball. With Julio Jones questionable to play with a hamstring injury and A.J. Brown off to an especially slow start, Tannehill simply doesn’t have the weapons or pass protection to go blow-for-blow with Allen. Circle those wagons and get ready for a blowout.
Final Score Prediction: Buffalo 34, Titans 17.
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