NFL Week 13 Odds: Game Lines, Picks and Predictions

  • Go to Bovada for updated NFL Week 13 odds – spreads, moneylines, over/unders and more
  • Sean McVay is 6-0 versus Arizona all-time and the Cardinals have lost three of their last four games
  • The Colts should cover the -3.0 points on the road against a Houston team without receiver Will Fuller and cornerback Bradley Roby

While the Ravens and Steelers have still yet to play their Week 12 game that was originally schedule for Thanksgiving night, that won’t stop us from looking ahead to Week 13.

After looking at the latest game lines, we’ll provide our winning bets on all the NFL’s best matchups. However, be sure to check Bovada and BetOnline later in the week for odds on both the Washington/Pittsburgh and Dallas/Baltimore contests, which have been rescheduled for Monday and Tuesday, respectively.

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WEEK 13 NFL ODDS

Game Spread Moneyline Over/Under
Bengals vs.
Dolphins
+11.5 (-110)
-11.5 (-110)
+410
-620
Over 42.0 (-110)
Under 42.0 (-110)
Browns vs.
Titans
+6.0 (-115)
-6.0 (-105)
+215
-260
Over 54.0 (-110)
Under 54.0 (-110)
Lions vs.
Bears
+3.0 (-105)
-3.0 (-115
+150
-170
Over 44.5 (-105)
Under 44.5 (-115)
Colts vs.
Texans
-3.0 (-110)
+3.0 (-110)
-160
+140
Over 51.5 (-105)
Under 51.5 (-115)
Jaguars vs.
Vikings
+9.5 (-110)
-9.5 (-110)
+340
-480
Over 52.0 (-110)
Under 52.0 (-110)
Raiders vs.
Jets
-8.0 (-105)
+8.0 (-115)
-380
+290
Over 47.0 (-115)
Under 47.0 (-105)
Saints vs.
Falcons
-3.0 (-115)
+3.0 (-105)
-170
+150
Over 46.0 (-110)
Under 46.0 (-110)
Rams vs.
Cardinals
-3.0 (-110)
+3.0 (-110)
-155
+135
Over 48.5 (-110)
Under 48.5 (-110)
Patriots vs.
Chargers
-1.0 (-105)
+1.0 (-115)
-115
+105
Over 47.0 (-110)
Under 47.0 (-110)
Eagles vs.
Packers
+9.0 (-115)
-9.0 (-105)
+310
-420
Over 47.0 (-105)
Under 47.0 (-115)
Broncos vs.
Chiefs
+14.0 (-110)
-14.0 (-110)
+600
-1000
Over 51.0 (-110)
Under 51.0 (-110)
Bills vs.
49ers
-2.5 (-115)
+2.5 (-105)
-145
+125
Over 48.0 (-110)
Under 48.0 (-110)

TOP WEEK 13 MATCHUPS

Sean McVay said his starting quarterback”must take better care of the ball” after Jared Goff threw two interceptions and lost a fumble in Sunday’s 23-20 loss to the Niners. As long as he does that, the Rams should have no trouble against a Cardinals club that has lost three of their last four and struggled to move the ball against New England last weekend.

Los Angeles’ defense is much better than the Patriots’ D and McVay is 6-0 versus Arizona since coming aboard in 2017. Rams (-3.0 at Bovada)

A team without a home, the 49ers will host the Bills from the Cardinals stadium in Glendale, Arizona on Monday night. Buffalo is 0-4 on MNF since 2015, but they’re 4-1 straight-up in their past five games against NFC teams, with their only loss coming on the “Hail Murray”.

The injury-ravaged 49ers are getting lauded for their upset victory over the Rams, but they did have an extra week of preparation coming off their bye week. With dozens of players still on the sidelines and no stadium to call home, we expect the reigning NFC Champions to fall back to earth a bit against the Bills. Buffalo (-2.5 at Bovada)


With 8-3 records, both the Titans and Browns like beating up opponents with run-first game plans so jumping out to an early lead will be important for each side. After giving up an average of just 17 points over the past four games, Cleveland’s defense will get game-wrecker Myles Garrett back in the lineup but will be without cornerback Denzel Ward.

This has the makings of a close game, but much like their bruising back Derrick Henry, Tennessee is hitting their stride down the stretch, coming off two big wins against the Ravens and Colts. And Cleveland has gone 1-10 ATS in their last 11 road games. Titans (-6.0 at Bovada)

BEST BETS OF THE WEEK

Deshaun Watson has 15 TDs and no interceptions in his last six games, but he’ll be without Will Fuller for the remainder of the year after the speedy receiver was busted for PEDs, along with cornerback Bradley Roby. The Colts had a tough go versus the Titans in Week 12, but they were missing star DT DeForest Buckner, who was placed on the Reserve/COVID-19 list.

In a dog fight for a playoff spot in the AFC, expect Indianapolis’ defense to bounce back against a Texans offense that is getting far too much credit for destroying a Matt Patricia coached Lions team on Thanksgiving. Colts (-3.0 at Bovada)  

The Chargers keep getting respect from oddsmakers because they have Offensive Rookie of the Year Justin Herbert throwing touchdown bombs every weekend, but sadly, they also have head coach Anthony Lynn whose poor play-calling and game management has turned what could have been a playoff team into a 3-8 operation.

In perhaps the greatest coaching mismatch of all time, Bill Belichick should be able to keep things close enough for Lynn to mess up in the final minutes. The Patriots offense is downright ugly, but Los Angeles’ defense has allowed 27 points or more in eight straight games. New England (+1.0 at Bovada)

Steve Dominey

Steve has almost 15 years of experience in marketing, PR and sports television. After acquiring a Journalism degree from Carleton University, he assembled highlight packs for Canada's most-watched sports network (TSN) before transitioning to a career in communications. He describes himself as a good father, great dog owner, and mediocre gambler and husband.