NFL Week 5 Picks and Predictions for all of Sunday’s Games

  • BetOnline has NFL Week 5 lines, spreads and over/unders for every game on the Sunday slate
  • Patrick Mahomes and the Chiefs are 2.5-point home favorites versus Josh Allen’s Bills
  • The Browns are 1-point road underdogs to the Chargers in a matchup between two of the best young coaches in the league

Sunday should help sort out the pecking order in the AFC with the Super Bowl favorites in Kansas City hosting the Bills, and the 3-1 Cleveland Browns heading to SoFi Stadium in Los Angeles to face Justin Herbert and the 3-1 Chargers.

Over in the NFC, Kyler Murray and his undefeated Cardinals will play host to their NFC West rivals in San Francisco as No. 2 overall pick Trey Lance takes the reins from oft-injured Jimmy Garoppolo after back-to-back Niners losses.

Let’s look at the Week 5 money lines, totals and point spreads. But before we do, here’s where you can find tips and advice on betting on NFL football games, as well as Super Bowl and NFL MVP futures.

NFL Week 5 – Sunday Slate

BetOnlineSpreadMoney LineTotal Points
New York Jets+3 (-111)+140Ov 46 (-112)
Atlanta Falcons-3 (-109)-160Un 46 (-108)
Miami Dolphins+10½ (-115)+385Ov 48(-110)
Tampa Bay Buccaneers-10½ (-105)-475Un 48 (-110)
Philadelphia Eagles+4 (-111)+162Ov 45 (-108)
Carolina Panthers-4 (-109)-182Un 45 (-112)
New Orleans Saints-1 (-125)-130Ov 44.5 (-110)
Washington Football Team+1 (+105)+110Un 44.5 (-110)
Tennessee Titans-4 (-113)-192Ov 48.5 (-118)
Jacksonville Jaguars+4 (-107)+167Un 48.5 (-102)
Detroit Lions+7½ (-115)+280Ov 49.5 (-110)
Minnesota Vikings-7½ (-105)-350Un 49.5 (-110)
Denver Broncos+1 (-110)Ov 40 (-105)
Pittsburgh Steelers-1 (-110)Un 40 (-115)
Green Bay Packers-3 (-112)-160Ov 50.5 (-115)
Cincinnati Bengals+3 (-108)+140Un 50.5 (-105)
New England Patriots-9 (-112)-410Ov 39.5 (-110)
Houston Texans+9 (-108)+330Un 39.5 (-110)
Chicago Bears+5½ (-104)Ov 44.5 (-110)
Las Vegas Raiders-5½ (-116)Un 44.5 (-110)
Cleveland Browns+1 (-105)+105Ov 48 (-110)
Los Angeles Chargers-1 (-115)-125Un 48 (-110)
New York Giants+7 (-114)+265Ov 52.5 (-112)
Dallas Cowboys-7 (-106)-315Un 52.5 (-108)
San Francisco 49ers+5½+205Ov 45.5 (-110)
Arizona Cardinals-5½-245Un 45.5 (-110)
Buffalo Bills+2½+135Ov 49 (-110)
Kansas City Chiefs-2½-155Un 49 (-110)

Bills (+2.5) over Chiefs

We can expect fireworks in Arrowhead on Sunday night when two of the three highest-scoring teams in the NFL meet up in an AFC Championship Game rematch. Just as the Chiefs poured resources into their offensive line in the offseason, Buffalo added to their defense via the draft and the early returns have been promising.

Sean McDermott’s club has given up the fewest points per game (11) in the league, already notching two shutouts in the first month of the season, while Kansas City’s D has permitted the second-most points and yards in the NFL. After outscoring their last three opponents by a combined score of 118-21, it’s hard to bet against the Bills.

Chargers (-1.0) over Browns

Completing just 53.1% of his passes over the past two weeks, Baker Mayfield was downright stinky in a 14-7 victory over Minnesota on Sunday. Luckily, his Browns should be able to let Nick Chubb and Kareem Hunt loose against the Chargers’ bottom-five run defense.

After tossing seven touchdowns in wins over the Chiefs and Raiders the past two weeks, Justin Herbert will have his work cut out for him against a Cleveland defense that ranks second in the NFL. This matchup between 2020 Coach of the Year Kevin Stefanski and 2021 COY frontrunner Brandon Staley is a tough one to call, but we give Los Angeles the edge since the Browns’ three wins have come against Houston, Chicago and Cleveland.

Buffalo BillsTo Cover Spread
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+2.5
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Los Angeles ChargersTo Cover Spread
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-1.0
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49ers (+5.5) over Cardinals

In one corner, you have NFL MVP frontrunner Kyler Murray and the undefeated Cardinals. In the other, raw rookie Trey Lance and a Niners team that’s six-games under .500 in Kyle Shanahan’s four-plus years in the Bay Area.

While it hardly seems like a fair fight, Arizona has lost its past two home game against San Francisco, who will be coming into the game desperate and hungry after consecutive losses to the Packers and Seahawks. The Niners will lose, but keep it close.

Tasty teaser of the week

Teasers are one of my favorite weekly plays. To explain how they work – you basically get to move the line six points in your direction. This week, our five-leg teaser includes the Vikings (teased from -7.5 points down to -1.5), Buccaneers (-4.5), Patriots (-3.0), Cowboys (-1.0) and Raiders (+0.5), paying out on BetOnline at +400 of whatever investment you’re comfortable with. Good luck!

San Francisco 49ersTo Cover Spread
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+5.5
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.