NFL Week 1 Picks And Predictions For Opening Weekend

  • BetOnline has NFL Week 1 lines, spreads and over/unders for every game on the Sunday slate
  • Kyle Shanahan and the 49ers should get creative against the lowly Detroit Lions
  • Alabama quarterbacks Mac Jones and Tua Tagovailoa square off when the Dolphins host the Patriots

While one would think watching football all day would be the perfect way to unwind at the end of the week, NFL Sundays are actually quite stressful. After your morning coffee, you’ve got to look up the latest injury news, set your fantasy lineups, and check the latest game lines before laying down some wagers.

Then, you’ve got to sweat the results of every game over the course of 11 hours while over-eating and drinking. If you win your matchups and bets, the day can be viewed as a success. But if you lose… boy, it’s hard to get up on Monday sometimes.

Sound familiar? With the 2021 NFL Opening Weekend just a few days away, let’s take a look at the lines for Sunday’s afternoon football action and make our picks. Here’s also where you can get tips and advice on betting on NFL football games and Super Bowl futures.

NFL Week 1 – Sunday Slate

BetOnlineSpreadMoney LineTotal Points
Pittsburgh Steelers+6½ (-110)+235Ov 48½ (-110)
Buffalo Bills-6½ (-110)-280Un 48½ (-110)
New York Jets+5 (-105)+200Ov 44½ (-110)
Carolina Panthers-5 (-115)-240Un 44½ (-110)
Jacksonville Jaguars-2½ (-125)-150Ov 45 (-105)
Houston Texans+2½ (+105)+130Un 45 (-115)
Arizona Cardinals+3 (-115)+138Ov 52 (-110)
Tennessee Titans-3 (-105)-158Un 52 (-110)
Los Angeles Chargers-1 (-108)-118Ov 44½ (-110)
Washington Football Team+1 (-112)-102Un 44½ (-110)
Philadelphia Eagles+3½ (-112)+155Ov 48½ (-110)
Atlanta Falcons-3½ (-108)-175Un 48½ (-110)
Seattle Seahawks-2½ (-110)-145Ov 48½ (-110)
Indianapolis Colts+2½ (-110)+125Un 48½ (-110)
Minnesota Vikings-3½ (+102)-165Ov 48½ (-110)
Cincinnati Bengals+3½ (-122)+145Un 48½ (-110)
San Francisco 49ers-7½ (-104)-330Ov 46 (-108)
Detroit Lions+7½ (-116)+275Un 46 (-112)
Cleveland Browns+6½ (-120)+225Ov 53 (-105)
Kansas City Chiefs-6½ (+100)-265Un 53 (-115)
Miami Dolphins+2½ (-105)+130Ov 43½ (-105)
New England Patriots-2½ (-115)-150Un 43½ (-115)
Denver Broncos-2½ (-120)-152Ov 42 (-110)
New York Giants+2½ (+100)+132Un 42 (-110)
Green Bay Packers-4½ (-115)-210Ov 50½ (-110)
New Orleans Saints+4½ (-105)+175Un 50½ (-110)

Jaguars (-2.5) over Texans

Early returns on the Urban Meyer era in Jacksonville haven’t been great – but losing to this Texans roster would be a tragedy for any team. Surely, No. 1 overall pick Trevor Lawrence will find a way to put up points against Houston’s mediocre expansion-team roster. Can an offense led by Tyrod Taylor, Mark Ingram and Brandin Cooks really win a game in the year 2021?

Jacksonville JaguarsTo Cover Spread
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-2.5
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49ers (-7.5) over Lions

While they’ll play hard under knee-biter Dan Campbell, the Lions will be overmatched by Kyle Shanahan’s offensive shenanigans in this one. Expect Jimmy Garoppolo to start and Trey Lance to make a few cameo appearances in a blowout win for San Francisco.

San Francisco 49ersTo Cover Spread
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-7.5
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Patriots (-2.5) over Dolphins

It’s a battle of Alabama quarterbacks – but one team seems much more confident in its starter. Bill Belichick cut Cam Newton to pave the way for the Mac Jones to start while rumor mill whispers say the Dolphins are trying to replace Tua Tagovailoa with accused sex criminal Deshaun Watson. Regardless of which signal caller looks better, the Patriots are much better on both lines and will manhandle Miami in the trenches.

New England PatriotsTo Cover Spread
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-2.5
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Broncos (-2.5) over Giants

If Justin Fields or Mac Jones star in their rookie seasons, new Broncos GM George Paton will take on more heat for his inexplicable decision to draft cornerback Patrick Surtain and roll with Teddy Bridgewater at quarterback. However, a game against turnover-machine Daniel Jones and the Giants could be just the thing Denver needs to change the narrative. Look for Vic Fangio’s defense to feast while Teddy Two Gloves plays his uninspiring brand of turnover-free football.


Denver BroncosTo Cover Spread
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-2.5
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Steve Dominey

Steve has almost 15 years of experience in marketing, PR and sports television. After acquiring a Journalism degree from Carleton University, he assembled highlight packs for Canada's most-watched sports network (TSN) before transitioning to a career in communications. He describes himself as a good father, great dog owner, and mediocre gambler and husband.