NFL Week 2 Picks and Predictions for all of Sunday’s Games

  • BetOnline has NFL Week 2 lines, spreads and over/unders for every game on the Sunday slate
  • Sunday Night Football will see NFL MVPs Patrick Mahomes and Lamar Jackson square off
  • Chandler Jones and the Cardinals are 3.5-point home favorites against Kirk Cousins’ Vikings

Week 1 of the NFL season always brings a fair share of surprises and this year was no different with the Bills, Browns, Colts, Packers, Ravens and Titans (all 11-game winners in 2020) losing their season openers. In total, nine of 16 underdogs won outright and 12 of 16 underdogs covered the closing spread.

Will this week bring more upsets and chaos? Let’s look at the Week 2 money lines, totals and point spreads and place our bets without overreacting too much to what we witnessed in the first week of the 2021 season. But before we do, here’s where you can get tips and advice on betting on NFL football games and Super Bowl futures.

NFL Week 2 – Sunday Slate

BetOnlineSpreadMoney LineTotal Points
New Orleans Saints-3 (-125)-180Ov 44½ (-115)
Carolina Panthers+3 (+105)+160Un 44½ (-105)
Houston Texans+12½ (-107)+525Ov 48 (-112)
Cleveland Browns-12½ (-113)-725Un 48 (-108)
Cincinnati Bengals+1 (+108)+123Ov 45 (-110)
Chicago Bears-1 (-128)-143Un 45 (-110)
Las Vegas Raiders+5½ (-108)+210Ov 47 (-110)
Pittsburgh Steelers-5½ (-112)-250Un 47 (-110)
Buffalo Bills-3½ (-110)-177Ov 47½ (-113)
Miami Dolphins+3½ (-110)+157Un 47½ (-107)
Los Angeles Rams-4 (-105)-190Ov 47½ (-115)
Indianapolis Colts+4 (-115)+165Un 47½ (-105)
San Francisco 49ers-3 (-120)-190Ov 50 (-105)
Philadelphia Eagles+3 (+100)+165Un 50 (-115)
Denver Broncos-6 (-107)-255Ov 45½ (-110)
Jacksonville Jaguars+6 (-113)+215Un 45½ (-110)
New England Patriots-6 (-105)-250Ov 42 (-110)
New York Jets+6 (-115)+210Un 42 (-110)
Minnesota Vikings+3.5 (-110)+165Ov 51 (-110)
Arizona Cardinals-3.5 (-110)-190Un 51 (-110)
Atlanta Falcons+12½ (-115)+515Ov 52 (-110)
Tampa Bay Buccaneers-12½ (-105)-665Un 52 (-110)
Tennessee Titans+5.5 (-110)+205Ov 54 (-115)
Seattle Seahawks-5.5 (-110)-245Un 54 (-105)
Dallas Cowboys+3 (+105)+152Ov 55½ (-107)
Los Angeles Chargers-3 (-125)-172Un 55½ (-113)
Kansas City Chiefs-3½ (-110)-190Ov 55½ (-110)
Baltimore Ravens+3½ (-110)+165Un 55½ (-110)

Saints (-3.0) over Panthers

Was Jameis Winston’s five-touchdown performance against the Packers a mirage? We might find out when the Saints line up against the Panthers’ young, underrated defense. Then again, we also might discover Sam Darnold is still Sam Darnold if New Orleans plays the same brand of lockdown defense that mystified Aaron Rodgers in Week 1.

New Orleans SaintsTo Cover Spread
star iconstar iconstar iconstar iconstar icon
-3.0
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Bengals (+1.0) over Bears

Two of the league worst offensive lines will be in full matador mode in Chicago this Sunday as Andy Dalton seeks to win a “revenge game” against the Bengals before inevitably getting benched for rookie Justin Fields. After Matthew Stafford picked the Bears secondary apart in the opener (156.1 passer rating), Joe Burrow should be able to make sweet music with Ja’Marr Chase and Tee Higgins on the outside.

Cardinals (-3.5) over Vikings

Chandler Jones might knock Kirk Cousins out of action before COVID gets a chance. His five sacks highlighted a dominant Cardinals defensive performance in a 38-13 shellacking of the Titans in Week 1. The Vikings D didn’t look so bad against Cincinnati either, surrendering only six points in the game’s final 34 minutes, but stopping early NFL MVP candidate Kyler Murray will prove impossible in Arizona’s home opener.

Arizona CardinalsTo Cover Spread
star iconstar iconstar iconstar iconstar icon
-3.5
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Broncos (-6.0) over Giants

Give Urban Meyer some credit. At least he didn’t pack up and leave before Jacksonville’s home opener. With their coach possibly en route to USC, the Jaguars have little chance of hanging with the Broncos after allowing almost 300 passing yards and 160 rushing yards to the expansion-like Houston Texans last week. Denver hit the NFC schedule lottery, opening their season with the Giants, Jags and next week – the Jets!

Chiefs (-3.5) over Ravens

Once the heart of their team, Baltimore’s defense got tuned up on Monday Night Football by Derek Carr and the Raiders Minus their top two backs, the Ravens offense also looked nothing like the juggernaut it was in Lamar Jackson’s 2019 MVP campaign. That’s bad news given Lamar hasn’t beaten the Chiefs in three tries and got blown out by KC on MNF last year.

Kansas City ChiefsTo Cover Spread
star iconstar iconstar iconstar iconstar icon
-3.5
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.