NFL Week 3 Picks and Predictions for all of Sunday’s Games

  • BetOnline has NFL Week 3 lines, spreads and over/unders for every game on the Sunday slate
  • The Los Angeles Rams are 1-point home underdogs to the Tampa Bay Buccaneers on Sunday
  • Kansas City is a 6.5-point favorite over the Chargers and has failed to cover once in their past 13 games

Like every year, Week 2 saw plenty of teams fall back to earth after looking unstoppable in their season openers. The Saints, Eagles, Steelers and Bengals all disappointed their overexcited fan bases while Tennessee, Dallas, Green Bay, Buffalo and Cleveland righted the ship.

What’s in store this NFL Sunday? Let’s look at the Week 3 money lines, totals and point spreads and place our bets without overreacting too much to what we witnessed in the first week of the 2021 season. But before we do, here’s where you can get tips and advice on betting on NFL football games and Super Bowl futures.

NFL Week 3 – Sunday Slate

BetOnlineSpreadMoney LineTotal Points
Arizona Cardinals-7.5 (-106)-355Ov 52 (-110)
Jacksonville Jaguars+7.5 (-114)+285Un 52 (-110)
Indianapolis Colts+5 (-102)+210Ov 48 (-110)
Tennessee Titans-5 (-118)-250Un 48 (-110)
Baltimore Ravens-9 (+100)-380Ov 49.5 (-108)
Detroit Lions+9 (-120)+210Un 49.5 (-112)
Washington Football Team+8.5 (-110)+315Ov 45.5 (-110)
Buffalo Bills-8.5 (-110)-385Un 45.5 (-110)
New Orleans Saints-3 (-118)+130Ov 41.5 (-111)
New England Patriots+3 (-102)-150Un 41.5 (-109)
Los Angeles Chargers+6.5 (-110)+250Ov 56 (-110)
Kansas City Chiefs-6.5 (-110)-300Un 56 (-110)
Atlanta Falcons+3 (-112)+135Ov 48 (-110)
New York Giants-3 (-108)-155Un 48 (-110)
Chicago Bears+7 (-110)+260Ov 46.5 (-107)
Cleveland Browns-7 (-110)-310Un 46.5 (-113)
Cincinnati Bengals+3.5 (-109)+166Ov 43.5 (-110)
Pittsburgh Steelers-3.5 (-111)-191Un 43.5 (-110)
Miami Dolphins+3.5 (-112)Ov 45.5 (-110)
Las Vegas Raiders-3.5 (-108)Un 45.5 (-110)
New York Jets+10.5 (-115)+460Ov 41 (-110)
Denver Broncos-10.5 (-105)-600Un 41 (-110)
Tampa Bay Buccaneers-1 (-112)-127Ov 55.5 (-106)
Los Angeles Rams+1 (-108)+107Un 55.5 (-114)
Seattle Seahawks-2 (-110)-131Ov 55 (-110)
Minnesota Vikings+2 (-110)+111Un 55 (-110)
Green Bay Packers+3.5 (-117)+155Ov 50 (-110)
San Francisco 49ers-3.5 (-103)-175Un 50 (-110)

Patriots (-3.0) over Saints

Hopefully the cameras catch Bill Belichick and Sean Payton chatting before the game because they definitely have a lot to commiserate about. After the Patriots struggled without Tom Brady last season, New Orleans found out that life without Drew Brees wasn’t going to be so easy, falling 26-7 to Carolina on Sunday. Jameis Winston was picked off twice by the Panthers and now faces a New England defense that intercepted Jets rookie Zack Wilson four times.

New England PatriotsTo Cover Spread
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-3.0
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Cardinals (-7.5) over Jaguars

Just when you thought life couldn’t get any better for a Kyler Murray fantasy owner… the NFL MVP frontrunner heads to Jacksonville for a matchup with fellow No. 1 overall pick Trevor Lawrence. Sitting second in the NFL in passing yardage (689) and passing touchdowns (7) with 51 yards and two scores on the ground, the 24-year-old is going to destroy Urban Meyer and the Jaguars this Sunday.

Chargers (+6.5) over Chiefs

Following a 36-35 loss to Baltimore, the Chiefs have only covered the spread once in their past 13 games. Patrick Mahomes has 680 passing yards and six touchdowns against just an interception in two games, however, Brandon Staley’s Chargers defense held the Cowboys explosive offense to just 20 points last week. Los Angeles’ run D allowed 198 rushing yards and two scores in that one, but draft bust Clyde Edwards-Helaire will be much easier to contain.

Los Angeles ChargersTo Cover Spread
star iconstar iconstar iconstar iconstar icon
+6.5
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Buccaneers (-1.0) over Rams

This potential NFL Championship Game preview will have a huge impact on next week’s Super Bowl futures. Expect Matthew Stafford and the Rams to come out throwing as the Bucs have the second-worst passing defense in the NFL through two games, allowing 684 yards through the air to the Cowboys and Falcons. Good thing Tom Brady is well-equipped to keep up in a shootout, already passing for 655 yards and nine touchdowns this season.

49ers (-3.5) over Packers

While Aaron Rodgers righted the ship with a 35-17 home victory over the Lions on Monday night, Kyle Shanahan’s 49ers will prove difficult to prepare for on a short week. Especially for defensive coordinator Joe Barry, who has struggled in his first two weeks on the job in Green Bay. The Packers walloped the Niners last season but San Francisco had the upper hand in 2019, scoring blowout victories in the regular season and NFC Conference Championship.

San Francicso 49ersTo Cover Spread
star iconstar iconstar iconstar iconstar icon
-3.5
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.