NFL Week 18 Game Picks and Predictions

  • BetOnline has NFL Week 18 lines, spreads and over/unders for every Saturday and Sunday game
  • The Chargers are 2.5-point road favorites over the Chargers in a winner-take-all finale to the 2021 season
  • San Francisco (+4) needs a win against the NFC West rival Rams to secure a berth in the postseason

Exercise caution before placing any wagers on the first-ever Week 18 of the NFL season. With some teams having already clinched a playoff spot and others eliminated from postseason play altogether, determining who’s motivated to win this weekend can be tricky.

We’ll examine the full slate of games and offer some smart bets to capitalize on. Also, be sure to check out the best betting sites for NFL football in 2021 and get advice on how to bet on the NFL playoffs.

NFL Week 18 – Saturday and Sunday games

BetOnlineSpreadMoney LineTotal Points
Kansas City Chiefs-10 (-106)-435Ov 43.5 (-110)
Denver Broncos+10 (-114)355Un 43.5 (-110)
Dallas Cowboys-7½ (-101)-300Ov 42.5 (-110)
Philadelphia Eagles+7½ (-119)250Un 42.5 (-110)
Green Bay Packers-2 (-110)Ov 42 (-110)
Detroit Lions+2 (-110)Un 42 (-110)
Chicago Bears+2½ (-110)120Ov 44.5 (-110)
Minnesota Vikings-2½ (-110)-140Un 44.5 (-110)
Indianapolis Colts-16 (-105)-1050Ov 44.5 (-110)
Jacksonville Jaguars+16 (-115)675Un 44.5 (-110)
Tennessee Titans-10 (-112)-525Ov 42.5 (-110)
Houston Texans+10 (-108)420Un 42.5 (-110)
Washington Football Team-6½ (-113)-290Ov 38.5 (-105)
New York Giants+6½ (-107)245Un 38.5 (-115)
Pittsburgh Steelers+3½ (-110)169Ov 41.5 (-115)
Baltimore Ravens-3½ (-110)-194Un 41.5 (-105)
Cincinnati Bengals-1 (-115)Ov 42 (-115)
Cleveland Browns+1 (-105)Un 42 (-105)
New England Patriots-7 (-110)-310Ov 40 (-110)
Miami Dolphins+7 (-110)260Un 40 (-110)
New York Jets+16½ (-110)635Ov 43.5 (-110)
Buffalo Bills-16½ (-110)-870Un 43.5 (-110)
Carolina Panthers+8 (-110)Ov 42.5 (-110)
Tampa Bay Buccaneers-8 (-110)Un 42.5 (-110)
New Orleans Saints-4½ (-108)-210Ov 40 (-108)
Atlanta Falcons+4½ (-112)180Un 40 (-112)
Seattle Seahawks+6½ (-105)230Ov 48 (-110)
Arizona Cardinals-6½ (-115)-275Un 48 (-110)
San Francisco 49ers+4185Ov 42.5 (-110)
Los Angeles Rams-4-215Un 42.5 (-110)
Los Angeles Chargers-2½-140Ov 42.5 (-110)
Las Vegas Raiders+2½120Un 42.5 (-110)

Raiders (+2.5) over Chargers

The 2021 season concludes with a “winner-take-all” game between the Chargers and Raiders on Sunday Night Football, unless this unlikely scenario unfolds. Left for dead after suffering a 48-9 loss to the Chiefs in Week 14, Las Vegas has rallied to a 9-7 record with three straight victories over the Browns, Broncos and Colts. With star tight end Darren Waller set to return to the lineup, we expect the resilient Raiders to win a tight game over a Chargers franchise with a rich history of coming up small in big moments.

Jaguars (+16) over Colts

Everyone will have an eye on this one. Why? If the Colts win, they’re in. But if the NFL’s worst franchise was to score an upset victory at home, that would open the playoff door for the winner of the Ravens vs. Steelers game (assuming the Chargers and Raiders don’t work together to secure a tie on Sunday night). Somehow, some way, Indianapolis hasn’t won in Jacksonville since 2014. While that streak should end this weekend, the 2-14 Jaguars will be plenty motivated to keep things closer than their AFC South rivals would like.

Las Vegas RaidersTo Cover vs. Chargers
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+2.5
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Jacksonville JaguarsTo Cover vs. Colts
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+16
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49ers (+4) over Rams

San Francisco clinches a postseason berth with a win over Los Angeles or a Saints loss to the Falcons. However, Sean McVay’s club will also be plenty motivated because they need a win to clinch the NFC West title and a first-round home game in the playoffs. Given the 49ers have won five in a row in this series, including a 31-10 victory back in November, and are facing a more dire “do or die” scenario, we like Kyle Shanahan to empty out the cupboard of Trey Lance plays to secure a W and a playoff spot.

Rest Scenarios To Capitalize On

With the Green Bay Packers having already clinched the NFC’s No. 1 seed, the Detroit Lions (+2) are a strong bet to pick up their third win of the season. Cincinnati will also have nothing to play for if the Chiefs defeat the Broncos on Saturday, so we expect Joe Burrow and the Bengals star receiver duo to rest against a Browns club trying to finish strong with Case Keenum under center. Take Cleveland (+2.5) while you can.

It’s also fair to wonder how motivated the Buccaneers will be to secure the NFC’s No. 2 seed given they’d also need a Rams loss to earn it. Expect Tampa Bay to pull its starters after the first half, giving the Panthers an excellent shot to cover the 8 points.

Cleveland BrownsTo Cover vs. Bengals
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+2.5
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.