NHL Game Picks for Thursday, April 21, 2022

  • BetOnline has point spreads, money lines and game totals for the 11 NHL games on Thursday, April 21, 2022
  • Auston Matthews has missed two-straight games with an undisclosed injury heading into the Leafs matchup with the Tampa Bay Lightning
  • Vancouver desperately needs a road win over Minnesota to keep their slim playoff hopes alive

The Stanley Cup Playoffs get underway in just over a week, but the playoff seeds are nowhere close to set. Tonight’s 11 games will go a long way in determining what teams face off in the postseason with do-or-die matchups across the league.

Let’s check the odds for all of Thursday’s National Hockey League action. Here’s also where you can find the top betting sites for NHL hockey in 2022 and smart wagering tips in our 2022 Stanley Cup betting guide.

NHL Games – Thursday, April 21

BetOnlineSpreadMoney LineTotal Points
Detroit Red Wings+470Ov 7 (+110)
Florida Panthers-550Un 7 (-121)
Buffalo Sabres+119Ov 6.5 (-105)
New Jersey Devils-131Un 6.5 (-105)
Philadelphia Flyers+119Ov 6 (+100)
Montreal Canadiens-131Un 6 (-110)
Boston Bruins+110Ov 6 (+104)
Pittsburgh Penguins-121Un 6 (-115)
Winnipeg Jets+218Ov 6 (-108)
Carolina Hurricanes-245Un 6 (-102)
New York Rangers-130Ov 5.5 (-103)
New York Islanders+118Un 5.5 (-107)
Toronto Maple Leafs+100Ov 6.5 (-120)
Tampa Bay Lightning-110Un 6.5 (+109)
Vancouver Canucks+153Ov 6 (-113)
Minnesota Wild-170Un 6 (+102)
St. Louis Blues-183Ov 6 (-113)
San Jose Sharks+165Un 6 (+102)
Dallas StarsTBATBA
Calgary FlamesTBATBA
Chicago BlackhawksTBATBA
Los Angeles KingsTBATBA

Penguins vs Bruins

After defeating the Penguins 2-1 on Saturday, Boston ended St. Louis’ nine-game winning streak with a 3-2 overtime victory on Tuesday. However, the Bruins will still be without David Pastrnak and Hampus Lindholm for their rematch with Pittsburgh on Thursday. Sidney Crosby and company haven’t played since that last meeting with the B’s and should have the fresh legs required to even the score.

Final score prediction: Penguins 4, Bruins 2

Lightning vs Maple Leafs

In a potential playoff preview, the Maple Leafs head to the Sunshine State looking to extend their four-game win streak. Tampa Bay is just 4-4-2 in their past 10 games, and likely wouldn’t mind dropping from third-place in the Atlantic to a Wild-Card spot. This would lock-in a postseason matchup with the Hurricanes, rather than the Leafs. Of course, the two-time defending Stanley Cup champs probably wouldn’t take steps to avoid a franchise that hasn’t won a playoff series since 2004, but it’s fun to speculate.

Final score prediction: Lightning 4, Leafs 3 OT

Toronto Maple Leafsto win Stanley Cup
Bet now
Boston Bruinsto win Stanley Cup
Bet now

Wild vs Canucks

Playing inspired hockey for Bruce Boudreau, the Canucks had won six straight before a costly 4-3 overtime-loss to Ottawa on Tuesday. But it might be a case of too little, too late for Vancouver, which is still four points behind the Kings for the final playoff spot in the Pacific with only five games left to play. Meanwhile, Minnesota is a blazing hot 7-1-2 in their last 10 and have the fifth-best home record (27-7-2) in the NHL. Look for the Wild to officially end the Canucks’ playoff chances on Thursday night.

Final score prediction: Wild 3, Canucks 1

Panthers vs Red Wings

Winners of 11 in a row, the Panthers are seeking their first President’s Trophy in franchise history. Sitting just two points back of the Avalanche, Florida should have no trouble knocking off a Red Wings squad that is under .500 in their past 10.

Final score prediction: Panthers 5, Red Wings 2

Islanders vs Rangers

When the year began, the Islanders were considered Cup contenders after consecutive trips to the Conference Finals. But it’s New York’s other hockey team that will be hosting a playoff game come May. The Rangers are coming off a 3-0 shutout of the Jets and will play Pittsburgh when the postseason gets underway the week after next. With nothing to play for, the Blueshirts will drop this one to their in-state rivals.

Final score prediction: Islanders 3, Rangers 2

Florida Panthersto win Stanley Cup
Bet now

See below the top sportsbooks where you can wager online and choose the best one for you:




50% up to $1,000

Bet Now




100% up to $1,000

Bet Now




125% Sports Bonus - up to $2,500

Bet Now

Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on heart-clogging eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

Learn how to find the best betting sites Here!