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Two struggling sides looking to spark a turnaround will face off in NHL action on October 15. The Ottawa Senators have managed just one win through their first three games of the season and now hit the road after a lopsided home defeat to the Nashville Predators. The Buffalo Sabres, meanwhile, have endured an even rougher start, dropping all three of their opening contests in regulation. Check out the latest odds and our betting predictions for the Senators vs. Sabres matchup below.
- What? NHL: Buffalo Sabres vs. Ottawa Senators
- Where? KeyBank Center, Buffalo
- When? Wednesday, October 15, 2025. 7:00pm ET
Buffalo Sabres vs. Ottawa Senators Odds
Below are the NHL betting lines for the match from three of the best Hockey betting sites.
| NHL |  |  |  |
| Ottawa Senators | -125 | -125 | -125 |
| Buffalo Sabres | -102 | -102 | -102 |
| Ottawa Senators -1.5 | +192 | +192 | +192 |
| Buffalo Sabres +1.5 | -255 | -255 | -255 |
| Over 6 | -113 | -113 | -113 |
| Under 6 | -112 | -112 | -112 |
Odds are subject to change.
Buffalo Sabres
Lindy Ruff’s Buffalo Sabres have stumbled out of the gate to begin the new NHL season. The home side is still searching for its first victory after dropping each of its opening three contests in regulation. Defensive issues have been a major concern, with the team already conceding ten goals through those games.
Their struggles continued in the most recent matchup, a 3-1 loss to the Colorado Avalanche, where Tage Thompson provided the lone bright spot by netting Buffalo’s only goal.
Ottawa Senators
The Senators opened the season on a promising note with a hard-fought victory over the Tampa Bay Lightning, giving fans reason for optimism.
But that early momentum has quickly evaporated after back-to-back lopsided losses to the Florida Panthers and Nashville Predators.
During those two defeats, Ottawa surrendered ten goals in total, including four in their most recent home setback against Nashville, where Ridly Greig netted the team’s lone tally in the final period.
The Senators will welcome a major boost as Drake Batherson is set to make his season debut against Buffalo. The talented winger, who missed the first three games with an upper-body injury, has been cleared to return and should immediately slot back into Ottawa’s top six. His presence adds much-needed scoring punch and playmaking ability to a team that’s struggled to generate offense in recent outings. Batherson’s return could also rejuvenate the power play, which has looked stagnant early in the season. If he finds chemistry quickly, the Senators could rediscover the attacking rhythm that fueled their opening-night victory.
Buffalo Sabres vs. Ottawa Senators Prediction and Betting Picks
Both teams are off to disappointing starts, but Ottawa has shown slightly more structure and scoring balance early on. While the Senators’ defensive play has been suspect, their offensive depth gives them a slight edge against a Buffalo team that’s looked disorganized and leaky at the back. Lindy Ruff’s Sabres are still adjusting to new systems, and with confidence at a low, this looks like a good spot for Ottawa to bounce back on the road. Expect the Senators to capitalize on Buffalo’s early-season defensive lapses and grind out a much-needed win.
Despite both teams’ defensive woes, neither has been firing consistently on offense. The Sabres have scored just four goals through their first three games, while Ottawa has managed only one goal in each of their last two outings. With both sides struggling to find rhythm in the attacking zone, this matchup could turn into a cautious, low-event battle rather than a shootout. The goaltenders should have an opportunity to steady their form, making the under 6 goals an appealing choice for bettors expecting a tighter contest.
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