US Open 2021 Tennis Betting Picks

The final Grand Slam of the 2021 tennis season is here! Get ready for it with our US Open 2021 tennis betting picks.

Best Bets to Win the 2021 ATP US Open

To Win the 2021 Mens US OpenBetOnline
Novak Djokovic-150
Daniil Medvedev+400
Alexander Zverev+550
Stefanos Tsitsipas+800
Matteo Berrettini+2500
Milos Raonic+3300
Andrey Rublev+4000
Jannik Sinner+4000
Denis Shapovalov+5000

More players are available to bet at BetOnline 

Novak Djokovic Goes for the Grand Slam

Although Novak Djokovic will not accomplish the Golden Slam – as the Summer Games did not go well for the World Number 1 – he still has a chance at the Grand Slam. Novak’s plowed through the competition in 2021 – winning the Australian Open, French Open, and Wimbledon. All that is left is the US Open betting – to become the first man ever to win the Grand Slam in a calendar year. It is clear why tennis betting markets have him as the favourite.

Djokovic is 75-12 all-time at the US Open with three wins (2011, 2015, and 2018). He has also reached the finals of the tournament five times. His losses in the Finals were against Rafael Nadal (twice), Roger Federer, Stan Wawrinka, and Andy Murray.

Sadly, Roger Federer and Rafael Nadal will miss the tournament (due to injuries). Stan Wawrinka is skipping. Andy Murray has qualified for the event but is past his prime. That leaves a relatively young class of players as the biggest challenge for the world no. one.

Time off since the Tokyo Olympics could also help Djokovic. He remains a master of his craft and would use the time to recover while still staying in excellent playing shape.

Some may think the pressure of completing the Calendar Slam is too much for Djokovic. His poor performance at the Olympics should not give you doubt about New York. Djokovic has never had success at the Summer Games. The US Open is somewhere he is frequently at his best.

Novak DjokovicTo Win the 2021 US Open
Bet now

Best Underdog to Bet will Win the 2021 US Open

Essentially everyone except for Djokovic is an underdog at the 2021 US Open. Daniil Medvedev is the second-highest ranked player behind Djokovic, but he has not looked the part recently. Alexander Zverev is coming off a win at the 2021 Cincinnati Open and was the runner-up at the US Open last year. However, we see better value than his at +550.

That brings us to Andrey Rublev at +4000. Rublev is in the midst of the greatest calendar year of his tennis career. He picked up a Gold Medal in the mixed doubles at the 2020 Summer Olympics, set career bests at three of four Grand Slams in the last year, and nearly knocked off Zverev to win the Cincinnati Open.

At the 2020 US Open, Rublev advanced to the quarterfinals for the second time in his career. His run to the quarterfinals was impressive. Rublev only dropped one set (of 12) over the first four rounds at the tournament. In the quarterfinals, he lost to Daniil Medvedev but took him to seven games in two of the three sets.

In the Cincinnati semi-finals, he exacted some revenge against Daniil Medvedev to pick up his first win against the world number two. With reaching the Cincinnati Open Finals, he improved his record to 41-14 this year and 25-7 on hard courts. Package it all together, and you get Andrey Rublev as the best underdog to win the 2021 US Open.

Andrey RublevTo Win the 2021 US Open
Bet now

Best Bets to Win the WTA US Open

To Win the 2021 Womens US OpenBetOnline
Ashleigh Barty+300
Naomi Osaka+400
Aryna Sabalenka+800
Bianca Andreescu+1200
Iga Swiatek+1200
Simona Halep+1200
Karolina Pliskova+1400
Cori Cauff+1600
Garbine Muguruza+1600
Barbora Krejckova+2000

More players are available to bet at BetOnline 

Ashleigh Barty a Worthy Favourite to Bet

World no. one Ashleigh Barty opens the US Open as the favourite to win, and we believe she deserves to be. Barty is coming off an impressive win at the Cincinnati Masters. She cruised through the five rounds without dropping a set. She also won Wimbledon this year, dropping only two sets in seven rounds.

While Barty has not yet won the Women’s singles at the US Open, she has won at Arthur Ashe Stadium. She won the 2018 US Open Women’s Doubles tournament. She also made the finals again in 2019. Barty was absent from the US Open in 2020.

She has been excellent on the hard course over the last two seasons – with a record of 30-6. We expect her to continue her run and take home the third Grand Slam of her career.

Ashleigh BartyTo Win the 2021 US Open
Bet now

Ons Jabeur is Live at +3300

Our favourite underdog on the women’s side to win the 2021 US Open is Ons Jabeur. She is coming into the tournament off her best performances at the French Open (fourth round), Wimbledon (quarters) and US Open (third round).

Jabeur has her best winning percentage this season at 72% – thanks to her first career win (the Birmingham Classic). She played well at the Canadian Masters and Cincinnati Open, going 5-2. Some notable wins in that stretch include one against world no. seven Bianca Andreescu and world no. eight Iga Swiatek.

It’s a good stretch for a player who looks like she is right on the edge of entering her prime. We like the value of her winning the women’s tournament at +3300.

Ons JabeurTo Win the 2021 US Open
Bet now

Top Sportsbooks to Bet on the 2021 US Open

Find the top online sportsbooks to bet on the 2021 US Open below. New users who join through the links underneath can receive an exclusive welcome bonus!




50% up to $1,000

Bet Now




100% up to $1,000

Bet Now




125% Sports Bonus - up to $2,500

Bet Now
Jason Flash

Jason Flash started out as an English major but has since moved into copywriting following up his passion for putting pen to paper. He has a deep knowledge of sports, having grown up playing college football and taking a keen interest in major league sports. Today he's producing content for sports across the globe, with a focus on the American market. When he's not working, you can find him climbing mountains on his roadbike.

Discover the top betting sites Here!