NFL Week 10 Odds: Game Lines, Picks and Predictions

  • Go to Bovada for the latest NFL Week 10 odds – spreads, moneylines, over/unders and more
  • Cleveland’s Nick Chubb is set to return against the Texans’ league-worst rushing defense
  • The Vikings are 3-point road favorites over the Bears on Monday night despite Kirk Cousins’ 0-9 career record in primetime

Rather than continue to shift and postpone games in midst of the pandemic, the NFL has decided to maintain a firm schedule moving forward, as the undermanned 49ers found out last Thursday night.

However, with Ben Roethlisberger added to the reserve/COVID-19 list this week, that means the Steelers/Bengals game is currently off the board, as is the Washington/Detroit matchup as we wait for an update on the health of Lions quarterback Matthew Stafford.

Let’s look at the latest odds for the remaining 12 matchups across the NFL and discuss some of our favorite plays of the week.

WEEK 10 NFL ODDS

Game Spread Moneyline Over/Under
Colts vs.
Titans
+2.0 (-110)
-2.0 (-110)
+115
-135
Over 48.5 (-110)
Under 48.5 (-110)
Texans vs.
Browns
+3.0 (EVEN)
-3.0 (-120)
+150
-170
Over 53.5 (-110)
Under 53.5 (-110)
Jaguars vs.
Packers
+14.0 (-110)
-14.0 (-110)
+650
-1100
Over 52.0 (-110)
Under 52.0 (-110)
Eagles vs.
Giants
-3.5 (-105)
+3.5 (-115)
-170
+150
Over 44.5 (-110)
Under 44.5 (-110)
Buccaneers vs.
Panthers
-6.0 (-110)
+6.0 (-110)
-260
+215
Over 50.5 (-110)
Under 50.5 (-110)
Bills vs.
Cardinals
+2.0 (-115)
-2.0 (-105)
+110
-130
Over 56.0 (-115)
Under 56.0 (-105)
Broncos vs.
Raiders
+5.5 (-110)
-5.5 (-110)
+200
-240
Over 52.0 (-110)
Under 52.0 (-110)
Chargers vs.
Dolphins
+3.0 (-120)
-3.0 (EVEN)
+125
-145
Over 48.0 (-110)
Under 48.0 (-110)
49ers vs.
Saints
+9.5 (-105)
-9.5 (-115)
+320
-440
Over 50.0 (-110)
Under 50.0 (-110)
Seahawks vs.
Rams
+1.5 (-110)
-1.5 (-110)
+105
-125
Over 55.5 (-110)
Under 55.5 (-110)
Ravens vs.
Patriots
-7.5 (-105)
+7.5 (-115)
-350
+275
Over 43.0 (-110)
Under 43.0 (-110)
Vikings vs.
Bears
-3.0 (EVEN)
+3.0 (-120)
-150
+130
Over 45.0 (-110)
Under 45.0 (-110)

BEST BETS FOR NFL WEEK 10

After blowing four leads of 16 points or more in four straight games, the Chargers decided to break their fans’ hearts in a different way on Sunday against the Raiders as tight end Donald Parham dropped a potential game-winning touchdown at the buzzer. Of course, they would have had more time if coach Anthony Lynn had managed the clock properly.

With Lynn’s coaching blunders continuing to lead to gut-wrenching losses for Los Angeles, it’s easy to bet on a 5-3 Dolphins team that keeps getting better under head coach Brian Flores. In a matchup of rookie quarterbacks, we like Tua Tagovailoa to score the win over Justin Herbert, even if the latter looks like the better prospect moving forward. Miami (-3.0)   

Freed from Bill O’Brien’s shackles, Deshaun Watson continued to play inspired football against Jacksonville on Sunday, but it’s hard to get too excited about a two-point victory over the 1-7 Jaguars. Meanwhile, their Week 10 opponent will likely have star running back Nick Chubb back in the lineup.

With Chubb and Kareem Hunt once again forming the league’s best ground game, the Browns should run all over a Houston team that allows a league-worst 159.5 rushing yards per game. Cleveland (-3.0)  

MORE WINNING PICKS

The Buccaneers were flat-out embarrassed by the Saints on Sunday night, causing a huge shift in Super Bowl futures, while Carolina was hugely impressive in almost upsetting the Chiefs at home. Still, we like Tampa Bay to rebound against a Panthers defense that is sacking opposing quarterbacks on just 2.6 percent of dropbacks, the lowest mark in all of football.

While Tom Brady is connecting on just 44.0 percent of his passes under pressure, he’s completing 71.2 percent from a clean pocket with a 108.1 QB Rating. When given time, the 43-year-old can still get it done. Tampa Bay (-6.0)

Moving to the Monday Nighter, the Vikings are three-point road favorites against a Bears team that now has lost three straight after a 5-1 start to the season. While Chicago’s Nick Foles-led offense continues to make viewers want to gauge out their eyes, Minnesota has won consecutive games against divisional opponents thanks to Dalvin Cook, who put up 478 yards from scrimmage and six touchdowns against the Packers and Lions.

Still, let’s not forget the Vikings are a 3-5 team who have lost 16 of their last 19 at Soldier Field dating back to 2001. Kirk Cousins also has an ugly 0-9 career record on Monday Night Football. Chicago (+3.0) (+130 moneyline)

Steve Dominey

Steve has almost 15 years of experience in marketing, PR and sports television. After acquiring a Journalism degree from Carleton University, he assembled highlight packs for Canada's most-watched sports network (TSN) before transitioning to a career in communications. He describes himself as a good father, great dog owner, and mediocre gambler and husband.