NFL Week 12 Odds: Game Lines, Picks and Predictions

  • Go to Bovada for the latest NFL Week 12 odds – spreads, moneylines, over/unders and more
  • The Chiefs are 3.5-point road favorites against a reeling Buccaneers team that has lost two of their past three games
  • New Orleans is 6-0 both straight-up and against-the-spread in the past six games without Drew Brees

With the announcement that the Ravens/Steelers primetime Thanksgiving clash (odds and best bet here) would be moved to Sunday, there is no reason to wake up from your turkey-induced nap on Thursday.

After all – you’re going to need to rest up for all the games this weekend. Let’s review the latest NFL lines and offer our best bets on the NFL’s premier Week 12 matchups.


Game Spread Moneyline Over/Under
Cardinals vs.
-2.5 (-115)
+2.5 (-105)
Over 49.5 (-115)
Under 49.5 (-105)
Raiders vs.
-3.0 (-110)
+3.0 (-110)
Over 55.0 (-110)
Under 55.0 (-110)
Chargers vs.
+5.5 (-110)
-5.5 (-110)
Over 53.5 (-110)
Under 53.5 (-110)
Dolphins vs.
-7.0 (-105)
+7.0 (-115)
Over 44.5 (-110)
Under 44.5 (-110)
Giants vs.
-6.0 (-110)
+6.0 (-110)
Over 43.0 (-110)
Under 43.0 (-110)
Titans vs.
+3.5 (-125)
-3.5 (+105)
Over 51.5 (-110)
Under 51.5 (-110)
Saints vs.
-6.0 (-110)
+6.0 (-110)
Over 43.5 (-110)
Under 43.5 (-110)
49ers vs.
+7.0 (-110)
-7.0 (-110)
Over 45.0 (-105)
Under 45.0 (-115)
Chiefs vs.
-3.5 (-110)
+3.5 (-110)
Over 56.0 (-110)
Under 56.0 (-110)
Bears vs.
+8.5 (-110)
-8.5 (-110)
Over 45.0 (-105)
Under 45.0 (-115)
Seahawks vs.
-5.0 (-115)
+5.0 (-105)
Over 50.0 (-105)
Under 50.0 (-115)


According to Next Gen Stats, Tom Brady is 0-for-19 on deep passes (20+ air yards) in his last four contests with a 0.0 passer rating. Meanwhile, Patrick Mahomes showed he was at the very top of his game in a Week 11 comeback win over the Raiders, throwing his first go-ahead TD pass in the final 2 minutes of regulation in his career.

As we pointed out in our weekly Super Bowl odds update, Tampa Bay’s defense has fallen off a cliff, allowing 27.7 points per game over the past month. There’s no reason to believe the Buccaneers can keep pace with the Chiefs, so the question becomes, will Brady continue his snub-streak and blow off Mahomes after the game? Kansas City (+3.5 at Bovada)

Both coming off big overtime wins, the 7-3 Colts and 7-3 Titans will square off for the second time in three weeks, and for sole possession of the first place in the AFC South.

Winners of four of their last five games, Indianapolis scored a 34-17 road victory against Tennessee in Week 10 to improve Frank Reich to 4-1 against Mike Vrabel in their three seasons coaching their respective clubs.

However, the Titans have proven to be a tough-as-nails team under Vrabel and should be plenty motivated to score revenge against the Colts and a hobbled Philip Rivers who missed practice on Wednesday with a toe injury. Tennessee (+3.5 at Bovada)

tampa bay buccaneers
“Doug Martin & Josh Freeman | Tampa Bay Buccaneers” by Seatacular is licensed under CC BY-NC-SA 2.0


It’s hard to be too confident when backing a Daniel Jones-quarterbacked team, but the Giants are playing hard under first-year coach Joe Judge, winning three of their past five games and almost upsetting the Bucs on the first Monday night of November.

Allowing only 20 points per game over their past five games, Big Blue will now have the opportunity to feast on an inexperienced Brandon Allen after Joe Burrow’s knee exploded last Sunday. New York (-6.0 at Bovada)

After sending Tua Tagovailoa to the bench, the Broncos defense will now welcome Taysom Hill to Mile High. Still, this is a unit that has yielded the sixth-most points in the NFL and ESPN Fantasy’s TE #1 looked strong in his first start at the QB position, running for two scores in a 24-9 win over Atlanta.

New Orleans has gone 6-0 both straight-up and against-the-spread in the past six games they’ve played without Drew Brees, and their defense has been borderline unbeatable in the second half of their past three games combined, permitting just six total points on two field goals.

The Saints should feast on the turnover-prone Drew Lock, who has averaged only 6.6 yards-per-attempt in eight starts this season, throwing seven touchdowns and 11 picks. New Orleans (-6.0 at Bovada)

Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on heart-clogging eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.

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