NFL Week 6 Picks and Predictions for all of Sunday’s Games

  • BetOnline has NFL Week 6 lines, spreads and over/unders for every game on the Sunday slate
  • Justin Herbert and the 4-1 Chargers are 3-point road underdogs to Lamar Jackson and the 4-1 Ravens
  • The Cowboys are 4.5 favorites in Foxborough but haven’t defeated the Patriots since 1996

It’s hard to believe but at the conclusion of this week’s games we’ll already be one-third of the way through the 2021 NFL season. Some of the early-year surprises so far are the Chiefs registering three losses in their first five games, the Cardinals being the league’s last undefeated team, and Jon Gruden being unemployed.

On the eve of another unpredictable slate of Sunday football games, let’s look at the Week 6 money lines, totals and point spreads. But before we do, here’s where you can find tips and advice on betting on NFL football, as well as Super Bowl and NFL MVP futures.

NFL Week 6 – Sunday Slate

BetOnlineSpreadMoney LineTotal Points
Miami Dolphins-3½ (-110)-190Ov 45.5 (-110)
Jacksonville Jaguars+3½ (-110)+165Un 45.5 (-110)
Green Bay Packers-4½ (-115)-215Ov 45 (-110)
Chicago Bears+4½ (-105)+185Un 45 (-110)
Kansas City Chiefs-6½ (-116)-300Ov 55.5 (-110)
Washington Football Team+6½ (-104)+250Un 55.5 (-110)
Minnesota Vikings+1½ (-110)+105Ov 46 (-107)
Carolina Panthers-1½ (-110)-125Un 46 (-113)
Los Angeles Chargers+3 (-105)+135Ov 51.5 (-115)
Baltimore Ravens-3 (-115)-160Un 51.5 (-105)
Cincinnati Bengals-3 (-110)-160Ov 47.5 (-110)
Detroit Lions+3 (-110)+140Un 47.5 (-110)
Los Angeles Rams-10½ (-114)-605Ov 47 (-115)
New York Giants+10½ (-106)+420Un 47 (-105)
Arizona Cardinals+2½ (+100)+128Ov 50.5 (-110)
Cleveland Browns-2½ (-120)-148Un 50.5 (-110)
Las Vegas Raiders+3½ (-107)+169Ov 44 (-110)
Denver Broncos-3½ (-113)-194Un 44 (-110)
Dallas Cowboys-4½ (-110)-205Ov 50 (-110)
New England Patriots+4½ (-110)+175Un 50 (-110)
Seattle Seahawks+4½ (-106)+191Ov 42.5 (-110)
Pittsburgh Steelers-4½ (-114)-221Un 42.5 (-110)

Packers (-4.5) over Bears

The Bears defense has been much-improved in 2021 under new defensive coordinator Sean Desai, with a league-leading team total of 15 sacks, but Chicago has won just one of their last 10 games against the Packers. Aaron Rodgers enjoys a 20-5 career record against the Bears with 55 touchdowns and 10 interceptions, and Green Bay should enter the divisional game focused after narrowly escaping Week 5 with a 25-22 overtime victory over the Bengals.

Cowboys (-4.5) over Patriots

Let’s keep riding the Cowboys, the only team in the NFL this season with a flawless 5-0 record against the spread. With six straight losses in the head-to-head series, Dallas hasn’t beat the Patriots since 1996, but we all know Tom Brady is heavily responsible for most of those Ws. Dak Prescott shouldn’t find the going too tough against a Bill Belichick defense that just allowed Davis Mills to carve them up for 313 passing yards and three touchdowns.

Green Bay PackersTo Cover vs Bears
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-4.5
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Dallas CowboysTo Cover vs Patriots
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-4.5
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Chargers (+3.0) over Ravens

In the game of the week, Justin Herbert and the 4-1 Chargers head to Baltimore to face a 4-1 Ravens club fresh off a thrilling 31-25 comeback victory over the Colts on Monday Night Football. Slowing down Lamar Jackson won’t be easy after the 2019 NFL MVP set a new NFL record for completion percentage (86%) in a 400-yard passing game with at least 40 attempts, but Brandon Staley and company already have wins over the Chiefs and Browns this season.

Browns (-2.5) over Cardinals

Fresh off allowing 47 points to the Chargers, Cleveland now has to find a way to stop Kyler Murray and the unbeaten Cardinals. The best defense might be a good offense in this case as Nick Chubb and Kareem Hunt should pile up yards against an Arizona defense that ranks bottom five in defensive rush success rate. Sure to be motivated against a fellow Oklahoma Heisman-winning quarterback, look for Baker Mayfield to make just enough plays to get the Browns back on track.

Cleveland BrownsTo Cover vs. Cardinals
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-2.5
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Steve Starr

Steve is one of the many Americans who spends Sunday watching football on the couch and gorging on delicious eats. He describes himself as a good father, great dog owner, and mediocre gambler and husband.