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- What? College Football Week 7
- Where? USA
- When? October 10 – 11, 2025
Week 7 of College Football brings a slate of high-profile matchups that are perfect for bettors looking to make their picks. Leading the charge is a Top-10 showdown between Oregon and Indiana, where the No. 3 Ducks are currently favored by 7.5 points over the No. 7 Hoosiers, according to the latest odds. Another marquee clash is the Red River Rivalry, pitting No. 6 Oklahoma against Texas. The Longhorns, led by Arch Manning, are slight 1-point favorites, though Oklahoma could be without quarterback John Mateer, who is reportedly pushing for a return.
Other notable Top 25 games this week feature Alabama taking on Missouri, with the Tigers listed as three-point underdogs in SEC action, and Ohio State facing Illinois, where the Buckeyes are 14-point favorites in Big Ten play. Additionally, the USC Trojans, despite being unranked, are drawing significant attention from bettors as they square off against Michigan, who enter as 2.5-point favorites. This clash between two historically elite programs is sure to be a focal point for Week 7 betting action.
Oregon vs. Indiana
Below are the NCAAF betting lines from three of the best College Football betting sites.
| NCAAF |  |  |  |
| Indiana | +235 | +235 | +241 |
| Oregon | -305 | -305 | -295 |
| Indiana +7.5 | -115 | -115 | -119 |
| Oregon -7.5 | -105 | -105 | -101 |
| Over 55 | -111 | -111 | -110 |
| Under 55 | -109 | -109 | -110 |
For this Indiana vs. Oregon matchup, the Ducks are listed as 7.5-point favorites at home, with the game total sitting at 55 points. Both squads enter Week 7 undefeated through five games. Oregon has a perfect record at home, winning and covering in all three contests, while Indiana secured a road victory but fell short of covering the spread in their lone away game. Offensively and defensively, the Hoosiers have shown slight edges, though Oregon benefits from playing in Eugene. Despite the line favoring the Ducks, this one projects to be extremely tight. Expect a hard-fought showdown between two of the nation’s top teams, with Indiana and the +7.5 points looking like the smarter play.
Oklahoma vs. Texas
The 42.5-point total for this year’s Red River Rivalry could hold hidden value, even with both teams boasting stout defenses. Oklahoma has excelled at stopping the run all season, while Texas has been exceptionally tough to pass against. Still, rivalry games often spark explosive plays, and this edition at the Cotton Bowl has shootout potential.
Arch Manning’s ability to extend plays and create big downfield opportunities could challenge an Oklahoma defense that hasn’t faced this type of versatile offense. Meanwhile, Oklahoma showed they can score in a hurry with a 44-point performance against Kent State with Hawkins under center, and they should be able to move the ball against the Longhorns. Historically, three of the last five Red River Rivalry games have gone over the total, making the over look like a strong option once again this year.
Alabama vs. Missouri
Last season, Alabama shut out Missouri 34-0 at home and has dominated the series, winning all five matchups while going 4-1 against the spread. Of those five games, the total went over three times.
For this week’s college football clash, Alabama enters as 3-point road favorites, with the total sitting at 52 points. Both programs have had strong campaigns so far—Missouri remains undefeated, while Alabama has dropped just one game. The Tigers are enjoying their sixth consecutive home contest, while the Crimson Tide are 1-1 away from home. Missouri has shown balanced strength on both sides of the ball and is averaging 30.6 points per game this season. Given the home-field edge and their dominant performances, Missouri and the +3 points look like the smarter play in this matchup.
Ohio State vs. Illinois
Ohio State should have little trouble putting points on the board against Illinois, but the bigger question is how much the Illini can muster against a stout Buckeyes defense. On the surface, Illinois’ offense looks heavily pass-oriented. Quarterback Luke Altmyer has been exceptional this season, throwing 12 touchdowns without a single interception.
The rushing numbers for Illinois tell a different story, averaging just 3.7 yards per carry, which ranks outside the nation’s top 100. That stat, however, masks some balance in their ground game. Running backs Calil Valentine and Kaden Feagin have each topped 300 yards and combined for eight rushing touchdowns. Altmyer’s negative 39 yards on carries has dragged down the overall rushing average, but Illinois’ offense is more multifaceted than it appears.
Ohio State is likely to shut down much of that ground attack, as they have against every other opponent, but the Illini could be the first team to reach double digits against the Buckeyes this year. Coupled with Ohio State’s explosive offense, the Over looks like a strong bet in this matchup.
USC Trojans vs. Michigan
This matchup promises excitement, with both programs ranking in the top 15 nationally in SP+ but employing very different approaches. Michigan comes in with the No. 7 SP+ offense but a middling No. 32 defense, while USC boasts the nation’s top offense paired with a No. 49 defense. The game could ultimately hinge on which quarterback can make the bigger impact in what has shootout potential on Saturday night in Los Angeles.
Michigan’s true freshman QB Bryce Underwood faces his first long-distance Big Ten road trip, and with the Wolverines’ passing game ranking just 51st in EPA per pass, USC defensive coordinator D’Anton Lynn should have a blueprint to limit Justice Haynes’ impact. On the other side, USC’s quarterback Maiava, supported by a deep arsenal of offensive weapons, has the firepower to exploit Michigan’s defensive vulnerabilities and keep the Wolverines on their heels.
Below is our partner table of the best offshore sportsbooks where you can place your College Football Week 7 bets.
Sports Betting Sites 