Best 2022 U.S. Open Bets: Rafael Nadal Has What It Takes to Regain No. 1 World Ranking

The qualifying rounds of the 2022 U.S. Open are done, and the real action began on Monday, August 29. Not surprisingly, we are itching to uncork our best bets to win it all. Since we already dropped our best bets to win the 2022 U.S. Open Women’s Championship, it’s on to the men’s division. And with Novak Djokovic unable to participate, we can’t help but wonder whether Rafael Nadal is poised to win the trophy for the first time since 2019.

Before we get into our top picks, here’s a look at the latest online betting options for the 2022 U.S. Open, courtesy of the folks from Bovada:

Pick to WinBovada
Daniil Medvedev+230
Rafael Nadal+380
Carlos Alcaraz+500
Nick Kyrgios+1000
Stefanos Tsitsipas+1600
Jannik Sinner+1800
Taylor Fritz+2200
Matteo Berrenttini+2900
Felix Auger-Aliassime+3600
Borna Coric+4000
Cameron Norrie+4500
Hubert Hurkacz+6500
Casper Ruud+6500
Andrey Rublev+12000
Pablo Carreno Busta+6500
Marin Cilic+6500
Denis Shapovalov+10000
Sebastian Korda+12000
Frances Tiafoe+13000
Dominic Thiem+14000
Jack Draper+14000
Robert Bautista Agut+15000
Andy Murray+16000
Alex de Minaur+16000
John Isner+17000
Botic van de Zandischulp+23000
Tommy Paul+25000
Karen Khachanov+23000
Miomir Kecmanovic+23000
Maxime Cressy+23000

Please remember to double-check these betting odds to win the 2022 U.S. Open until you actually place your wager. The men’s championship round won’t be taking place until Monday, September 12, so these tennis betting lines are bound to move a bunch as the tournament unfolds.

If you still need a place to bet on the 2022 U.S. Open, we’ve got you covered. Our reviews of the top rated online sportsbooks are designed to help you spot the best betting sites for all sports on the market.

Without further ado, let’s get to our top picks to win the 2022 U.S. Open Men’s Championship.

Should Rafael Nadal be Favored to Win It All?

It’s easy to come up with reasons why Rafael Nadal won’t win the 2022 U.S. Open. Not only is he 36, but he’s still working his way back from an abdominal injury that prompted him to miss a handful of important tournaments. His stamina might not be up to the heat and humidity he’s going to face in Flushing, New York.

Still, that’s not quite good enough to close the door on his going for a 23rd career Grand Slam title. Nadal remains one of the best tennis players in the world, someone who is closer to his prime than not. In fact, depending on how the bracket shakes out, a U.S. Open victory could vault him into the No. 1 spot on the world rankings latter.

Though it’s fair to be concerned about how Nadal’s abdominal injury could impact his serving, he continues to boast one of the craftiest ground games in existence. His change-of-pace strokes and ability to work pinpoint angles ensures he should ensure he’s playing into mid-September once more.

Rafael NadalTo win the 2022 U.S. Open
Bet now

Why Daniil Medvedev is Getting More Love Than Rafael Nadal

Surprised Daniil Medvedev is getting more love than Rafael Nadal? You shouldn’t be.

Medvedev is the world’s No. 1 player at this writing, and more than that, he’s also the defending U.S. Open Champion. Many have even speculated that he’s the no-brainer pick to win it all now that Novak Djokovic won’t be competing.

Controlling his first serve will be mission critical. Where someone like Rafael Nadal knows how to tone down the speed in favor of placement, Medvedev opts for power over everything. That’s entirely allowed when you’re still dropping in 60 percent of your first serves, but it can sometimes get him into trouble.

Beyond this, however, there’s not much cause for concern. Medvedev is winning 75 percent of his service games, and he’s getting better at forcing break opportunities after winning opening points.

Daniil MedvedevTo win the 2022 U.S. Open
Bet now

John Isner Could be an Interesting 2022 U.S. Open Dark Horse Bet

At 37, John Isner is not someone you should consider a favorite at the 2022 U.S. Open. That honor is reserved for players like Daniil Medvedev and Rafael Nadal. At the same time, players with size and huge serves can go on incredible runs when operating on the hard courts in Flushing. 

Isner falls under that umbrella. At 6’10”, he has a monster first serve, and it’s one he still converts nearly 70 percent of the time. Even more tantalizing, Isner continues to win 85 percent of his first serve points.

Indeed, this could be a very boom-or-bust proposition. Isner’s backhand has slowed down in recent years, and he cannot cover the baseline as well given his advanced age. But for those who have the iron stomach necessary to take risks, we also view Isner as more than just a stab-in-the-dark candidate.

John IsnerTo win the 2022 U.S. Open
Bet now

Carlos Alcaraz Could Leave 2022 U.S. Open as World’s No. 1

Carlos Alcaraz is yet another player who has a chance to finish as the World’s No. 1 if he wins the 2022 U.S. Open. Currently sitting in the No. 4 spot, he has started to sway even the loudest critics by creating one of the tour’s best all-around packages.

Sure, there are players who hit harder and faster. But Alcaraz has become a whiz at exhausting opponents with his placement on groundstrokes—especially his knack for pushing them back deep and then dropping in shallow looks.

Plenty of people worry about how his size (6’0″) will hold up when he comes to the net. But that should really only be an issue when going up against certain opponents. Overall, Alcaraz has a claim to be one of the two or three most well-rounded players in Flushing.

Carlos AlcarazTo win the 2022 U.S. Open
Bet now

2022 U.S. Open Men’s Prediction

There is a real appeal to going with Carlos Alcaraz and his 5-to-1 payout. The brand of tennis he’s been championing lately is beyond enviable.

In the end, though, we’re most drawn to Rafael Nadal.

There is some risk given his return from an abdominal injury, but it’s also been forever since he entered the U.S. Open paying out nearly 4-to-1. Given the relative lack of experience in this setting at the top of the bracket, this feels like an opportunity for him to remind the world that just because he’s older, it doesn’t mean he’s done.

MTS Prediction: Rafael Nadal (+380)

Rafael NadalTo win the 2022 U.S. Open
Bet now

Take a look at this list of the top online sportsbooks so you can decide which one to use for all of your 2022 U.S. Open betting:




50% up to $1,000

Bet Now




100% up to $1,000

Bet Now




125% Sports Bonus - up to $2,500

Bet Now
Xing Cai

Xing Cai is the son of immigrants living in San Francisco. He fell in love with baseball as a child and studied sports journalism in the California State University system. He currently lives in the Bay Area with his two dogs.

Find out everything about sports betting Here!